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Phospho-Tyrosine(s) vs. Phosphatidylinositol Binding in Shc Mediated Integrin Signaling
The Shc adaptor protein, particularly its p52 isoform, has been identified as a primary signaling partner for the tyrosine(s)-phosphorylated cytoplasmic tails of activated β(3) integrins. Inspired by our recent structure of the Shc PTB domain in complex with a bi-phosphorylated peptide derived from...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397963/ https://www.ncbi.nlm.nih.gov/pubmed/25893141 http://dx.doi.org/10.4236/ajmb.2015.52003 |