Cargando…

Identifying genes that mediate anthracyline toxicity in immune cells

The role of the immune system in response to chemotherapeutic agents remains elusive. The interpatient variability observed in immune and chemotherapeutic cytotoxic responses is likely, at least in part, due to complex genetic differences. Through the use of a panel of genetically diverse mouse inbr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Frick, Amber, Suzuki, Oscar T., Benton, Cristina, Parks, Bethany, Fedoriw, Yuri, Richards, Kristy L., Thomas, Russell S., Wiltshire, Tim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398020/ https://www.ncbi.nlm.nih.gov/pubmed/25926793 http://dx.doi.org/10.3389/fphar.2015.00062

Ejemplares similares

Immune cell-based screening assay for response to anticancer agents: applications in pharmacogenomics
por: Frick, Amber, et al.
Publicado: (2015)

A cellular genetics approach identifies gene-drug interactions and pinpoints drug toxicity pathway nodes
por: Suzuki, Oscar T., et al.
Publicado: (2014)

Transitioning Pharmacogenomics into the Clinical Setting: Training Future Pharmacists
por: Frick, Amber, et al.
Publicado: (2016)

Implementing Clinical Pharmacogenomics in the Classroom: Student Pharmacist Impressions of an Educational Intervention Including Personal Genotyping
por: Frick, Amber, et al.
Publicado: (2018)

Neurologic Toxicity of Immune Checkpoint Inhibitors: A Review of Literature
por: Albarrán, Víctor, et al.
Publicado: (2022)

Toxicity of Immune-Checkpoint Inhibitors in Hematological Malignancies
por: Hradska, Katarina, et al.
Publicado: (2021)

Optimal experimental design for efficient toxicity testing in microphysiological systems: A bone marrow application
por: Cairns, Jonathan, et al.
Publicado: (2023)

Neglected, Drug-Induced Platinum Accumulation Causes Immune Toxicity
por: Zhang, Yuling, et al.
Publicado: (2020)

Adverse Effects and Toxicity of Immune Checkpoint Inhibitors For Patients With Urothelial Carcinoma
por: Wang, Di, et al.
Publicado: (2021)

Potential role of gut microbes in the efficacy and toxicity of immune checkpoints inhibitors
por: Ma, Jingxin, et al.
Publicado: (2023)

Immune Checkpoint Inhibitor Toxicity in Head and Neck Cancer: From Identification to Management
por: Wang, Haiyang, et al.
Publicado: (2019)

Alkylating Agent-Induced Toxicity and Melatonin-Based Therapies
por: Egea, Javier, et al.
Publicado: (2022)

Cardiovascular Toxicity Induced by Chronic Vincristine Treatment
por: Herradón, Esperanza, et al.
Publicado: (2021)

Hematologic and lymphatic system toxicities associated with immune checkpoint inhibitors: a real-world study
por: Li, Na, et al.
Publicado: (2023)

Pulmonary Toxicities Associated With the Use of Immune Checkpoint Inhibitors: An Update From the Immuno-Oncology Subgroup of the Neutropenia, Infection & Myelosuppression Study Group of the Multinational Association for Supportive Care in Cancer
por: Rapoport, Bernardo L., et al.
Publicado: (2021)

Unsupervised Hierarchical Clustering Identifies Immune Gene Subtypes in Gastric Cancer
por: Cao, Jing, et al.
Publicado: (2021)

Study on Acute Toxicity of Amiodarone New Complexes With Cyclodextrin
por: Ghiciuc, Cristina Mihaela, et al.
Publicado: (2021)

Toxic Constituents Index: A Toxicity-Calibrated Quantitative Evaluation Approach for the Precise Toxicity Prediction of the Hypertoxic Phytomedicine—Aconite
por: Zhang, Ding-kun, et al.
Publicado: (2016)

Editorial: Animal Toxins as Comprehensive Pharmacological Tools to Identify Diverse Ion Channels
por: Utkin, Yuri, et al.
Publicado: (2019)

Screening of a Focused Ubiquitin-Proteasome Pathway Inhibitor Library Identifies Small Molecules as Novel Modulators of Botulinum Neurotoxin Type A Toxicity
por: Sen, Edanur, et al.
Publicado: (2021)

Toxicity of Tetradium ruticarpum: Subacute Toxicity Assessment and Metabolomic Identification of Relevant Biomarkers
por: Shan, Qiyuan, et al.
Publicado: (2022)

Evaluating genetic markers and neurobiochemical analytes for fluoxetine response using a panel of mouse inbred strains
por: Benton, Cristina S., et al.
Publicado: (2011)

Pericardial Toxicities Associated With Immune Checkpoint Inhibitors: A Pharmacovigilance Analysis of the FDA Adverse Event Reporting System (FAERS) Database
por: Ma, Zhuo, et al.
Publicado: (2021)

Metabolic Activation of the Toxic Natural Products From Herbal and Dietary Supplements Leading to Toxicities
por: Wang, Yi-Kun, et al.
Publicado: (2021)

A Qualitative Modeling Approach for Whole Genome Prediction Using High-Throughput Toxicogenomics Data and Pathway-Based Validation
por: Haider, Saad, et al.
Publicado: (2018)

Identifying effective diagnostic biomarkers and immune infiltration features in chronic kidney disease by bioinformatics and validation
por: Liu, Tao, et al.
Publicado: (2022)

Predictive Toxicity: Grand Challenges
por: Pelkonen, Olavi
Publicado: (2010)

Hydroxychloroquine-induced Retinal Toxicity
por: Yusuf, Imran H., et al.
Publicado: (2023)

Metabolomics Reveals the Mechanisms for the Pulmonary Toxicity of Siegesbeckia orientalis L. and the Toxicity-Reducing Effect of Processing
por: Jiang, Ting, et al.
Publicado: (2021)

Editorial: Toxicity Mechanisms, Exposure, Toxicokinetic and Risk Assessment Aspects of Metals, Toxic for Animals and Humans
por: Zhu, Yanzhu, et al.
Publicado: (2022)

Immune mediators as predictive biomarkers for anti-PD-1 antibody therapy in urothelial carcinoma
por: Shibata, Yosuke, et al.
Publicado: (2023)

Fluoxetine Prevents Aβ(1-42)-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth-Factor-β1
por: Caraci, Filippo, et al.
Publicado: (2016)

Plasma Metabolomics Identifies the Dysregulated Metabolic Profile of Primary Immune Thrombocytopenia (ITP) Based on GC-MS
por: Zhang, Ziyan, et al.
Publicado: (2022)

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury
por: Woodhead, Jeffrey L., et al.
Publicado: (2014)

How the Toxin got its Toxicity
por: Jackson, Timothy N. W., et al.
Publicado: (2020)

Editorial: Toxicity mechanisms, exposure, toxicokinetic and risk assessment aspects of metals, toxic for animals and humans, Volume II
por: Zhu, Yanzhu, et al.
Publicado: (2023)

Identifying hub genes, key pathways and key immune-related genes in Peyronie’s disease by integrated bioinformatic analysis
por: Cui, Yuanshan, et al.
Publicado: (2022)

A novel cell-based screen identifies chemical entities that reverse the immune-escape phenotype of metastatic tumours
por: Nohara, Lilian L., et al.
Publicado: (2023)

Erratum: A novel cell-based screen identifies chemical entities that reverse the immune-escape phenotype of metastatic tumours
por: Frontiers Production Office
Publicado: (2023)

In vitro Toxicity Testing in the Twenty-First Century
por: Roggen, Erwin L.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_acpch4kqn8p5o7v16im92c0eoh