Priming with a Simplified Intradermal HIV-1 DNA Vaccine Regimen followed by Boosting with Recombinant HIV-1 MVA Vaccine Is Safe and Immunogenic: A Phase IIa Randomized Clinical Trial

BACKGROUND: Intradermal priming with HIV-1 DNA plasmids followed by HIV-1MVA boosting induces strong and broad cellular and humoral immune responses. In our previous HIVIS-03 trial, we used 5 injections with 2 pools of HIV-DNA at separate sites for each priming immunization. The present study explor...

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Detalles Bibliográficos
Autores principales: Munseri, Patricia. J., Kroidl, Arne, Nilsson, Charlotta, Joachim, Agricola, Geldmacher, Christof, Mann, Philipp, Moshiro, Candida, Aboud, Said, Lyamuya, Eligius, Maboko, Leonard, Missanga, Marco, Kaluwa, Bahati, Mfinanga, Sayoki, Podola, Lilly, Bauer, Asli, Godoy-Ramirez, Karina, Marovich, Mary, Moss, Bernard, Hoelscher, Michael, Gotch, Frances, Stöhr, Wolfgang, Stout, Richard, McCormack, Sheena, Wahren, Britta, Mhalu, Fred, Robb, Merlin L., Biberfeld, Gunnel, Sandström, Eric, Bakari, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398367/
https://www.ncbi.nlm.nih.gov/pubmed/25875843
http://dx.doi.org/10.1371/journal.pone.0119629

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