Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIG

The use of high dose chemotherapy followed by autologous hematopoietic stem cell transplantation for remission consolidation after initial induction represents standard of care for patients with multiple myeloma. Patients with myeloma and Acquired von Willebrand Syndrome (AVWS) undergoing autologous...

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Autores principales: Zoghi, Behyar, Shaughnessy, Paul, Lyons, Roger M., Helmer, Richard, Bachier, Carlos, LeMaistre, C. Frederick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398961/
https://www.ncbi.nlm.nih.gov/pubmed/25922770
http://dx.doi.org/10.1155/2015/809313
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author Zoghi, Behyar
Shaughnessy, Paul
Lyons, Roger M.
Helmer, Richard
Bachier, Carlos
LeMaistre, C. Frederick
author_facet Zoghi, Behyar
Shaughnessy, Paul
Lyons, Roger M.
Helmer, Richard
Bachier, Carlos
LeMaistre, C. Frederick
author_sort Zoghi, Behyar
collection PubMed
description The use of high dose chemotherapy followed by autologous hematopoietic stem cell transplantation for remission consolidation after initial induction represents standard of care for patients with multiple myeloma. Patients with myeloma and Acquired von Willebrand Syndrome (AVWS) undergoing autologous stem cell transplant (ASCT) are at significant risk of bleeding due to the profound thrombocytopenia, low Factor VIII levels, fever, and toxicities associated with the preparative regimen. We report a patient with AVWS associated with multiple myeloma who underwent autologous stem cell transplants as consolidation after initial induction and again at relapse. He was successfully treated with high dose intravenous immunoglobulin (IVIG) prior to each transplant with rapid resolution of AVWS.
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spelling pubmed-43989612015-04-28 Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIG Zoghi, Behyar Shaughnessy, Paul Lyons, Roger M. Helmer, Richard Bachier, Carlos LeMaistre, C. Frederick Case Rep Hematol Case Report The use of high dose chemotherapy followed by autologous hematopoietic stem cell transplantation for remission consolidation after initial induction represents standard of care for patients with multiple myeloma. Patients with myeloma and Acquired von Willebrand Syndrome (AVWS) undergoing autologous stem cell transplant (ASCT) are at significant risk of bleeding due to the profound thrombocytopenia, low Factor VIII levels, fever, and toxicities associated with the preparative regimen. We report a patient with AVWS associated with multiple myeloma who underwent autologous stem cell transplants as consolidation after initial induction and again at relapse. He was successfully treated with high dose intravenous immunoglobulin (IVIG) prior to each transplant with rapid resolution of AVWS. Hindawi Publishing Corporation 2015 2015-04-02 /pmc/articles/PMC4398961/ /pubmed/25922770 http://dx.doi.org/10.1155/2015/809313 Text en Copyright © 2015 Behyar Zoghi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Zoghi, Behyar
Shaughnessy, Paul
Lyons, Roger M.
Helmer, Richard
Bachier, Carlos
LeMaistre, C. Frederick
Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIG
title Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIG
title_full Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIG
title_fullStr Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIG
title_full_unstemmed Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIG
title_short Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIG
title_sort treatment of acquired von willebrand syndrome and prevention of bleeding postautologous stem cell transplant during severe pancytopenia with ivig
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398961/
https://www.ncbi.nlm.nih.gov/pubmed/25922770
http://dx.doi.org/10.1155/2015/809313
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