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Basal expression of insulin-like growth factor 1 receptor determines intrinsic resistance of cancer cells to a phosphatidylinositol 3-kinase inhibitor ZSTK474

Drug resistance often critically limits the efficacy of molecular targeted drugs. Although pharmacological inhibition of phosphatidylinositol 3-kinase (PI3K) is an attractive therapeutic strategy for cancer therapy, molecular determinants for efficacy of PI3K inhibitors (PI3Kis) remain unclear. We p...

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Detalles Bibliográficos
Autores principales:	Isoyama, Sho, Kajiwara, Gensei, Tamaki, Naomi, Okamura, Mutsumi, Yoshimi, Hisashi, Nakamura, Naoki, Kawamura, Kento, Nishimura, Yumiko, Namatame, Nachi, Yamori, Takao, Dan, Shingo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399020/ https://www.ncbi.nlm.nih.gov/pubmed/25483727 http://dx.doi.org/10.1111/cas.12582

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