PAPSS2 Deficiency Causes Androgen Excess via Impaired DHEA Sulfation—In Vitro and in Vivo Studies in a Family Harboring Two Novel PAPSS2 Mutations

CONTEXT: PAPSS2 (PAPS synthase 2) provides the universal sulfate donor PAPS (3′-phospho-adenosine-5′-phosphosulfate) to all human sulfotransferases, including SULT2A1, responsible for sulfation of the crucial androgen precursor dehydroepiandrosterone (DHEA). Impaired DHEA sulfation is thought to inc...

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Detalles Bibliográficos
Autores principales: Oostdijk, Wilma, Idkowiak, Jan, Mueller, Jonathan W., House, Philip J., Taylor, Angela E., O'Reilly, Michael W., Hughes, Beverly A., de Vries, Martine C., Kant, Sarina G., Santen, Gijs W. E., Verkerk, Annemieke J. M. H., Uitterlinden, André G., Wit, Jan M., Losekoot, Monique, Arlt, Wiebke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2015
Materias:
JCEM Online: Advances in Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399300/
https://www.ncbi.nlm.nih.gov/pubmed/25594860
http://dx.doi.org/10.1210/jc.2014-3556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399300/
https://www.ncbi.nlm.nih.gov/pubmed/25594860
http://dx.doi.org/10.1210/jc.2014-3556

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