The role of death-associated protein 3 in apoptosis, anoikis and human cancer

Death-associated protein 3 (DAP3) is a molecule with a significant role in the control of both apoptosis and anoikis. Apoptosis is the predominant type of programmed cell death (PCD) which may occur in response to irreparable damage to DNA, or in response to induction by inflammatory cells. Anoikis...

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Autores principales: Wazir, Umar, Orakzai, Mona MAW, Khanzada, Zubair S, Jiang, Wen G, Sharma, Anup K, Kasem, Abdul, Mokbel, Kefah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399419/
https://www.ncbi.nlm.nih.gov/pubmed/25883535
http://dx.doi.org/10.1186/s12935-015-0187-z
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author Wazir, Umar
Orakzai, Mona MAW
Khanzada, Zubair S
Jiang, Wen G
Sharma, Anup K
Kasem, Abdul
Mokbel, Kefah
author_facet Wazir, Umar
Orakzai, Mona MAW
Khanzada, Zubair S
Jiang, Wen G
Sharma, Anup K
Kasem, Abdul
Mokbel, Kefah
author_sort Wazir, Umar
collection PubMed
description Death-associated protein 3 (DAP3) is a molecule with a significant role in the control of both apoptosis and anoikis. Apoptosis is the predominant type of programmed cell death (PCD) which may occur in response to irreparable damage to DNA, or in response to induction by inflammatory cells. Anoikis is subset of apoptosis which occurs in epithelial cells in response to detachment from the surrounding matrix. Both apoptosis and anoikis are of interest in the context of carcinogenesis. In this review, we shall discuss apoptosis and anoikis, and the recent literature regarding the role of DAP3 in both these pathways.
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spelling pubmed-43994192015-04-17 The role of death-associated protein 3 in apoptosis, anoikis and human cancer Wazir, Umar Orakzai, Mona MAW Khanzada, Zubair S Jiang, Wen G Sharma, Anup K Kasem, Abdul Mokbel, Kefah Cancer Cell Int Review Death-associated protein 3 (DAP3) is a molecule with a significant role in the control of both apoptosis and anoikis. Apoptosis is the predominant type of programmed cell death (PCD) which may occur in response to irreparable damage to DNA, or in response to induction by inflammatory cells. Anoikis is subset of apoptosis which occurs in epithelial cells in response to detachment from the surrounding matrix. Both apoptosis and anoikis are of interest in the context of carcinogenesis. In this review, we shall discuss apoptosis and anoikis, and the recent literature regarding the role of DAP3 in both these pathways. BioMed Central 2015-04-10 /pmc/articles/PMC4399419/ /pubmed/25883535 http://dx.doi.org/10.1186/s12935-015-0187-z Text en © Wazir et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Wazir, Umar
Orakzai, Mona MAW
Khanzada, Zubair S
Jiang, Wen G
Sharma, Anup K
Kasem, Abdul
Mokbel, Kefah
The role of death-associated protein 3 in apoptosis, anoikis and human cancer
title The role of death-associated protein 3 in apoptosis, anoikis and human cancer
title_full The role of death-associated protein 3 in apoptosis, anoikis and human cancer
title_fullStr The role of death-associated protein 3 in apoptosis, anoikis and human cancer
title_full_unstemmed The role of death-associated protein 3 in apoptosis, anoikis and human cancer
title_short The role of death-associated protein 3 in apoptosis, anoikis and human cancer
title_sort role of death-associated protein 3 in apoptosis, anoikis and human cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399419/
https://www.ncbi.nlm.nih.gov/pubmed/25883535
http://dx.doi.org/10.1186/s12935-015-0187-z
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