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Gangliocytic paraganglioma: a multi-institutional retrospective study in Japan

BACKGROUND: Gangliocytic paraganglioma (GP) is an extremely rare benign tumor that commonly arises from the second part of the duodenum. Since GP exhibit neither prominent mitotic activity nor Ki-67 immunoreactivity, this tumor is often misdiagnosed as neuroendocrine tumor (NET) G1 (carcinoid tumor)...

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Autores principales: Okubo, Yoichiro, Nemoto, Tetsuo, Wakayama, Megumi, Tochigi, Naobumi, Shinozaki, Minoru, Ishiwatari, Takao, Aki, Kyoko, Tsuchiya, Masaru, Aoyama, Hajime, Katsura, Kanade, Fujii, Takeshi, Nishigami, Takashi, Yokose, Tomoyuki, Ohkura, Yasuo, Shibuya, Kazutoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399421/
https://www.ncbi.nlm.nih.gov/pubmed/25886293
http://dx.doi.org/10.1186/s12885-015-1308-8
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author Okubo, Yoichiro
Nemoto, Tetsuo
Wakayama, Megumi
Tochigi, Naobumi
Shinozaki, Minoru
Ishiwatari, Takao
Aki, Kyoko
Tsuchiya, Masaru
Aoyama, Hajime
Katsura, Kanade
Fujii, Takeshi
Nishigami, Takashi
Yokose, Tomoyuki
Ohkura, Yasuo
Shibuya, Kazutoshi
author_facet Okubo, Yoichiro
Nemoto, Tetsuo
Wakayama, Megumi
Tochigi, Naobumi
Shinozaki, Minoru
Ishiwatari, Takao
Aki, Kyoko
Tsuchiya, Masaru
Aoyama, Hajime
Katsura, Kanade
Fujii, Takeshi
Nishigami, Takashi
Yokose, Tomoyuki
Ohkura, Yasuo
Shibuya, Kazutoshi
author_sort Okubo, Yoichiro
collection PubMed
description BACKGROUND: Gangliocytic paraganglioma (GP) is an extremely rare benign tumor that commonly arises from the second part of the duodenum. Since GP exhibit neither prominent mitotic activity nor Ki-67 immunoreactivity, this tumor is often misdiagnosed as neuroendocrine tumor (NET) G1 (carcinoid tumor). However, patients with GP may have a better prognosis than patients with NET G1. This fact emphasizes the importance of differentiating GP from NET G1, but few studies have reported the epidemiology and histopathology of GP because of its rarity. To differentiate GP from NET G1 with ease, we conducted a multi-institutional retrospective study analyzing the morphometric and immunohistochemical features of this tumor. METHODS: Since only a limited number of patients with GP could be identified in our institute, we conducted a multi-institutional retrospective study of GP in Japan, which was approved by the Ethics Committee of our medical institute. The obtained tissue sections underwent detailed morphometric and immunohistochemical analyses. Additionally, to differentiate GP from NET G1 with ease, immunohistochemical findings were compared. RESULTS: In our examination of 12 cases of duodenal GP, we found that epithelioid cells of GP exhibited positive reactivity for progesterone receptor and pancreatic polypeptide, whereas tumor cells of NET G1 were completely negative reactivity for both. Additionally, although GP is considered to be an extremely rare NET, we found that four (40.0%) of the ten patients at our institute with duodenal NET G1 actually had GP. CONCLUSIONS: Although GP is regarded as a rare NET, our results suggest that it accounts for a substantial percentage of duodenal NETs. Additionally, confirmation of immunoreactivity for progesterone receptor and pancreatic polypeptide can assist in differentiating GP from NET G1.
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spelling pubmed-43994212015-04-17 Gangliocytic paraganglioma: a multi-institutional retrospective study in Japan Okubo, Yoichiro Nemoto, Tetsuo Wakayama, Megumi Tochigi, Naobumi Shinozaki, Minoru Ishiwatari, Takao Aki, Kyoko Tsuchiya, Masaru Aoyama, Hajime Katsura, Kanade Fujii, Takeshi Nishigami, Takashi Yokose, Tomoyuki Ohkura, Yasuo Shibuya, Kazutoshi BMC Cancer Research Article BACKGROUND: Gangliocytic paraganglioma (GP) is an extremely rare benign tumor that commonly arises from the second part of the duodenum. Since GP exhibit neither prominent mitotic activity nor Ki-67 immunoreactivity, this tumor is often misdiagnosed as neuroendocrine tumor (NET) G1 (carcinoid tumor). However, patients with GP may have a better prognosis than patients with NET G1. This fact emphasizes the importance of differentiating GP from NET G1, but few studies have reported the epidemiology and histopathology of GP because of its rarity. To differentiate GP from NET G1 with ease, we conducted a multi-institutional retrospective study analyzing the morphometric and immunohistochemical features of this tumor. METHODS: Since only a limited number of patients with GP could be identified in our institute, we conducted a multi-institutional retrospective study of GP in Japan, which was approved by the Ethics Committee of our medical institute. The obtained tissue sections underwent detailed morphometric and immunohistochemical analyses. Additionally, to differentiate GP from NET G1 with ease, immunohistochemical findings were compared. RESULTS: In our examination of 12 cases of duodenal GP, we found that epithelioid cells of GP exhibited positive reactivity for progesterone receptor and pancreatic polypeptide, whereas tumor cells of NET G1 were completely negative reactivity for both. Additionally, although GP is considered to be an extremely rare NET, we found that four (40.0%) of the ten patients at our institute with duodenal NET G1 actually had GP. CONCLUSIONS: Although GP is regarded as a rare NET, our results suggest that it accounts for a substantial percentage of duodenal NETs. Additionally, confirmation of immunoreactivity for progesterone receptor and pancreatic polypeptide can assist in differentiating GP from NET G1. BioMed Central 2015-04-12 /pmc/articles/PMC4399421/ /pubmed/25886293 http://dx.doi.org/10.1186/s12885-015-1308-8 Text en © Okubo et al.; licensee BioMed Central. 2015 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Okubo, Yoichiro
Nemoto, Tetsuo
Wakayama, Megumi
Tochigi, Naobumi
Shinozaki, Minoru
Ishiwatari, Takao
Aki, Kyoko
Tsuchiya, Masaru
Aoyama, Hajime
Katsura, Kanade
Fujii, Takeshi
Nishigami, Takashi
Yokose, Tomoyuki
Ohkura, Yasuo
Shibuya, Kazutoshi
Gangliocytic paraganglioma: a multi-institutional retrospective study in Japan
title Gangliocytic paraganglioma: a multi-institutional retrospective study in Japan
title_full Gangliocytic paraganglioma: a multi-institutional retrospective study in Japan
title_fullStr Gangliocytic paraganglioma: a multi-institutional retrospective study in Japan
title_full_unstemmed Gangliocytic paraganglioma: a multi-institutional retrospective study in Japan
title_short Gangliocytic paraganglioma: a multi-institutional retrospective study in Japan
title_sort gangliocytic paraganglioma: a multi-institutional retrospective study in japan
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399421/
https://www.ncbi.nlm.nih.gov/pubmed/25886293
http://dx.doi.org/10.1186/s12885-015-1308-8
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