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ADP-ribose/TRPM2-mediated Ca(2+) signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells
Natural killer (NK) cells are essential for immunosurveillance against transformed cells. Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channel gated by ADP-ribose (ADPR). However, the role of TRPM2-mediated Ca(2+) signaling in the antitumor response of NK cells has...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399500/ https://www.ncbi.nlm.nih.gov/pubmed/25879940 http://dx.doi.org/10.1038/srep09482 |