ΔF508 CFTR Surface Stability Is Regulated by DAB2 and CHIP-Mediated Ubiquitination in Post-Endocytic Compartments

The ΔF508 mutant form of the cystic fibrosis transmembrane conductance regulator (ΔF508 CFTR) that is normally degraded by the ER-associated degradative pathway can be rescued to the cell surface through low-temperature (27°C) culture or small molecular corrector treatment. However, it is unstable o...

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Detalles Bibliográficos
Autores principales: Fu, Lianwu, Rab, Andras, Tang, Li ping, Bebok, Zsuzsa, Rowe, Steven M., Bartoszewski, Rafal, Collawn, James F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399842/
https://www.ncbi.nlm.nih.gov/pubmed/25879443
http://dx.doi.org/10.1371/journal.pone.0123131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399842/
https://www.ncbi.nlm.nih.gov/pubmed/25879443
http://dx.doi.org/10.1371/journal.pone.0123131

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