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17ß-Estradiol Regulates mTORC2 Sensitivity to Rapamycin in Adaptive Cardiac Remodeling

Adaptive cardiac remodeling is characterized by enhanced signaling of mTORC2 downstream kinase Akt. In females, 17ß-estradiol (E2), as well as Akt contribute essentially to sex-related premenopausal cardioprotection. Pharmacologic mTOR targeting with rapamycin is increasingly used for various clinic...

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Detalles Bibliográficos
Autores principales:	Kusch, Angelika, Schmidt, Maria, Gürgen, Dennis, Postpieszala, Daniel, Catar, Rusan, Hegner, Björn, Davidson, Merci M., Mahmoodzadeh, Shokoufeh, Dragun, Duska
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399939/ https://www.ncbi.nlm.nih.gov/pubmed/25880554 http://dx.doi.org/10.1371/journal.pone.0123385

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