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Selection against Heteroplasmy Explains the Evolution of Uniparental Inheritance of Mitochondria
Why are mitochondria almost always inherited from one parent during sexual reproduction? Current explanations for this evolutionary mystery include conflict avoidance between the nuclear and mitochondrial genomes, clearing of deleterious mutations, and optimization of mitochondrial-nuclear coadaptat...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400020/ https://www.ncbi.nlm.nih.gov/pubmed/25880558 http://dx.doi.org/10.1371/journal.pgen.1005112 |
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author | Christie, Joshua R. Schaerf, Timothy M. Beekman, Madeleine |
author_facet | Christie, Joshua R. Schaerf, Timothy M. Beekman, Madeleine |
author_sort | Christie, Joshua R. |
collection | PubMed |
description | Why are mitochondria almost always inherited from one parent during sexual reproduction? Current explanations for this evolutionary mystery include conflict avoidance between the nuclear and mitochondrial genomes, clearing of deleterious mutations, and optimization of mitochondrial-nuclear coadaptation. Mathematical models, however, fail to show that uniparental inheritance can replace biparental inheritance under any existing hypothesis. Recent empirical evidence indicates that mixing two different but normal mitochondrial haplotypes within a cell (heteroplasmy) can cause cell and organism dysfunction. Using a mathematical model, we test if selection against heteroplasmy can lead to the evolution of uniparental inheritance. When we assume selection against heteroplasmy and mutations are neither advantageous nor deleterious (neutral mutations), uniparental inheritance replaces biparental inheritance for all tested parameter values. When heteroplasmy involves mutations that are advantageous or deleterious (non-neutral mutations), uniparental inheritance can still replace biparental inheritance. We show that uniparental inheritance can evolve with or without pre-existing mating types. Finally, we show that selection against heteroplasmy can explain why some organisms deviate from strict uniparental inheritance. Thus, we suggest that selection against heteroplasmy explains the evolution of uniparental inheritance. |
format | Online Article Text |
id | pubmed-4400020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-44000202015-04-21 Selection against Heteroplasmy Explains the Evolution of Uniparental Inheritance of Mitochondria Christie, Joshua R. Schaerf, Timothy M. Beekman, Madeleine PLoS Genet Research Article Why are mitochondria almost always inherited from one parent during sexual reproduction? Current explanations for this evolutionary mystery include conflict avoidance between the nuclear and mitochondrial genomes, clearing of deleterious mutations, and optimization of mitochondrial-nuclear coadaptation. Mathematical models, however, fail to show that uniparental inheritance can replace biparental inheritance under any existing hypothesis. Recent empirical evidence indicates that mixing two different but normal mitochondrial haplotypes within a cell (heteroplasmy) can cause cell and organism dysfunction. Using a mathematical model, we test if selection against heteroplasmy can lead to the evolution of uniparental inheritance. When we assume selection against heteroplasmy and mutations are neither advantageous nor deleterious (neutral mutations), uniparental inheritance replaces biparental inheritance for all tested parameter values. When heteroplasmy involves mutations that are advantageous or deleterious (non-neutral mutations), uniparental inheritance can still replace biparental inheritance. We show that uniparental inheritance can evolve with or without pre-existing mating types. Finally, we show that selection against heteroplasmy can explain why some organisms deviate from strict uniparental inheritance. Thus, we suggest that selection against heteroplasmy explains the evolution of uniparental inheritance. Public Library of Science 2015-04-16 /pmc/articles/PMC4400020/ /pubmed/25880558 http://dx.doi.org/10.1371/journal.pgen.1005112 Text en © 2015 Christie et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Christie, Joshua R. Schaerf, Timothy M. Beekman, Madeleine Selection against Heteroplasmy Explains the Evolution of Uniparental Inheritance of Mitochondria |
title | Selection against Heteroplasmy Explains the Evolution of Uniparental Inheritance of Mitochondria |
title_full | Selection against Heteroplasmy Explains the Evolution of Uniparental Inheritance of Mitochondria |
title_fullStr | Selection against Heteroplasmy Explains the Evolution of Uniparental Inheritance of Mitochondria |
title_full_unstemmed | Selection against Heteroplasmy Explains the Evolution of Uniparental Inheritance of Mitochondria |
title_short | Selection against Heteroplasmy Explains the Evolution of Uniparental Inheritance of Mitochondria |
title_sort | selection against heteroplasmy explains the evolution of uniparental inheritance of mitochondria |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400020/ https://www.ncbi.nlm.nih.gov/pubmed/25880558 http://dx.doi.org/10.1371/journal.pgen.1005112 |
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