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Poly(ADP-ribosyl)ation of p53 Contributes to TPEN-Induced Neuronal Apoptosis

Depletion of intracellular zinc by N,N,N′,N′-tetrakis(2-pyridylmethyl) ethylenediamine (TPEN) induces p53-mediated protein synthesis-dependent apoptosis of mouse cortical neurons. Here, we examined the requirement for poly(ADP-ribose) polymerase (PARP)-1 as an upstream regulator of p53 in zinc deple...

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Detalles Bibliográficos
Autores principales:	Kim, Hyun-Lim, Ra, Hana, Kim, Ki-Ryeong, Lee, Jeong-Min, Im, Hana, Kim, Yang-Hee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Molecular and Cellular Biology 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400305/ https://www.ncbi.nlm.nih.gov/pubmed/25813624 http://dx.doi.org/10.14348/molcells.2015.2142

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