Infliximab as long-term maintenance in steroid-resistant and recurrent sarcoidosis in a renal transplant with central nervous system involvement

Sarcoidosis is a multisystemic, granulomatous disease of unknown aetiology, which commonly involves the lungs, skin and the eyes. Renal sarcoidosis is rare. Recurrent renal sarcoidosis leading to transplant graft failure in adults has not been reported. We report a single case of steroid-resistant s...

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Autores principales: Srivastava, Shalabh, Rajakariar, Ravindra, Ashman, Neil, Raftery, Martin, Brown, Heather, Martin, Joanne E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Clinical Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400454/
https://www.ncbi.nlm.nih.gov/pubmed/26069750
http://dx.doi.org/10.1093/ndtplus/sfr142
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author Srivastava, Shalabh
Rajakariar, Ravindra
Ashman, Neil
Raftery, Martin
Brown, Heather
Martin, Joanne E.
author_facet Srivastava, Shalabh
Rajakariar, Ravindra
Ashman, Neil
Raftery, Martin
Brown, Heather
Martin, Joanne E.
author_sort Srivastava, Shalabh
collection PubMed
description Sarcoidosis is a multisystemic, granulomatous disease of unknown aetiology, which commonly involves the lungs, skin and the eyes. Renal sarcoidosis is rare. Recurrent renal sarcoidosis leading to transplant graft failure in adults has not been reported. We report a single case of steroid-resistant sarcoid with recurrence in a renal transplant and the central nervous system that was managed with infliximab. We describe successful resolution of granulomas in the transplant kidney and stabilization of renal function with catastrophic central nervous system recurrence upon withdrawal of infliximab.
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spelling pubmed-44004542015-06-11 Infliximab as long-term maintenance in steroid-resistant and recurrent sarcoidosis in a renal transplant with central nervous system involvement Srivastava, Shalabh Rajakariar, Ravindra Ashman, Neil Raftery, Martin Brown, Heather Martin, Joanne E. Clin Kidney J Clinical Cases Sarcoidosis is a multisystemic, granulomatous disease of unknown aetiology, which commonly involves the lungs, skin and the eyes. Renal sarcoidosis is rare. Recurrent renal sarcoidosis leading to transplant graft failure in adults has not been reported. We report a single case of steroid-resistant sarcoid with recurrence in a renal transplant and the central nervous system that was managed with infliximab. We describe successful resolution of granulomas in the transplant kidney and stabilization of renal function with catastrophic central nervous system recurrence upon withdrawal of infliximab. Oxford University Press 2012-02 2012-01-28 /pmc/articles/PMC4400454/ /pubmed/26069750 http://dx.doi.org/10.1093/ndtplus/sfr142 Text en © The Author 2012. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Clinical Cases
Srivastava, Shalabh
Rajakariar, Ravindra
Ashman, Neil
Raftery, Martin
Brown, Heather
Martin, Joanne E.
Infliximab as long-term maintenance in steroid-resistant and recurrent sarcoidosis in a renal transplant with central nervous system involvement
title Infliximab as long-term maintenance in steroid-resistant and recurrent sarcoidosis in a renal transplant with central nervous system involvement
title_full Infliximab as long-term maintenance in steroid-resistant and recurrent sarcoidosis in a renal transplant with central nervous system involvement
title_fullStr Infliximab as long-term maintenance in steroid-resistant and recurrent sarcoidosis in a renal transplant with central nervous system involvement
title_full_unstemmed Infliximab as long-term maintenance in steroid-resistant and recurrent sarcoidosis in a renal transplant with central nervous system involvement
title_short Infliximab as long-term maintenance in steroid-resistant and recurrent sarcoidosis in a renal transplant with central nervous system involvement
title_sort infliximab as long-term maintenance in steroid-resistant and recurrent sarcoidosis in a renal transplant with central nervous system involvement
topic Clinical Cases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400454/
https://www.ncbi.nlm.nih.gov/pubmed/26069750
http://dx.doi.org/10.1093/ndtplus/sfr142
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