Oncogenic osteomalacia illustrating the effect of fibroblast growth factor 23 on phosphate homeostasis

In oncogenic osteomalacia (OOM), fibroblast growth factor 23 (FGF23) induces renal phosphate wasting and inhibits the appropriate increase of calcitriol. A patient suffering from OOM is described. Serum calcium, phosphate, biointact parathyroid hormone and intact FGF23 as well as the calcitriol and...

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Autores principales: Westerberg, Per-Anton, Linde, Torbjörn, Vanderschueren, Dirk, Billen, Jaak, Jans, Ivo, Ljunggren, Östen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Clinical Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400509/
https://www.ncbi.nlm.nih.gov/pubmed/26069775
http://dx.doi.org/10.1093/ckj/sfs031
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author Westerberg, Per-Anton
Linde, Torbjörn
Vanderschueren, Dirk
Billen, Jaak
Jans, Ivo
Ljunggren, Östen
author_facet Westerberg, Per-Anton
Linde, Torbjörn
Vanderschueren, Dirk
Billen, Jaak
Jans, Ivo
Ljunggren, Östen
author_sort Westerberg, Per-Anton
collection PubMed
description In oncogenic osteomalacia (OOM), fibroblast growth factor 23 (FGF23) induces renal phosphate wasting and inhibits the appropriate increase of calcitriol. A patient suffering from OOM is described. Serum calcium, phosphate, biointact parathyroid hormone and intact FGF23 as well as the calcitriol and 24,25-vitamin D levels were measured before and after tumour removal. The clinical approach to a patient with hypophosphataemia is discussed and the changes in mineral metabolism after removal of a FGF23-producing tumour are described.
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spelling pubmed-44005092015-06-11 Oncogenic osteomalacia illustrating the effect of fibroblast growth factor 23 on phosphate homeostasis Westerberg, Per-Anton Linde, Torbjörn Vanderschueren, Dirk Billen, Jaak Jans, Ivo Ljunggren, Östen Clin Kidney J Clinical Cases In oncogenic osteomalacia (OOM), fibroblast growth factor 23 (FGF23) induces renal phosphate wasting and inhibits the appropriate increase of calcitriol. A patient suffering from OOM is described. Serum calcium, phosphate, biointact parathyroid hormone and intact FGF23 as well as the calcitriol and 24,25-vitamin D levels were measured before and after tumour removal. The clinical approach to a patient with hypophosphataemia is discussed and the changes in mineral metabolism after removal of a FGF23-producing tumour are described. Oxford University Press 2012-06 2012-03-29 /pmc/articles/PMC4400509/ /pubmed/26069775 http://dx.doi.org/10.1093/ckj/sfs031 Text en © The Author 2012. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Clinical Cases
Westerberg, Per-Anton
Linde, Torbjörn
Vanderschueren, Dirk
Billen, Jaak
Jans, Ivo
Ljunggren, Östen
Oncogenic osteomalacia illustrating the effect of fibroblast growth factor 23 on phosphate homeostasis
title Oncogenic osteomalacia illustrating the effect of fibroblast growth factor 23 on phosphate homeostasis
title_full Oncogenic osteomalacia illustrating the effect of fibroblast growth factor 23 on phosphate homeostasis
title_fullStr Oncogenic osteomalacia illustrating the effect of fibroblast growth factor 23 on phosphate homeostasis
title_full_unstemmed Oncogenic osteomalacia illustrating the effect of fibroblast growth factor 23 on phosphate homeostasis
title_short Oncogenic osteomalacia illustrating the effect of fibroblast growth factor 23 on phosphate homeostasis
title_sort oncogenic osteomalacia illustrating the effect of fibroblast growth factor 23 on phosphate homeostasis
topic Clinical Cases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400509/
https://www.ncbi.nlm.nih.gov/pubmed/26069775
http://dx.doi.org/10.1093/ckj/sfs031
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