G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent

G-protein coupled receptors (GPCRs) constitute the largest class of membrane proteins and are a major drug target. A serious obstacle to studying GPCR structure/function characteristics is the requirement to extract the receptors from their native environment in the plasma membrane, coupled with the...

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Detalles Bibliográficos
Autores principales: Jamshad, Mohammed, Charlton, Jack, Lin, Yu-Pin, Routledge, Sarah J., Bawa, Zharain, Knowles, Timothy J., Overduin, Michael, Dekker, Niek, Dafforn, Tim R., Bill, Roslyn M., Poyner, David R., Wheatley, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400634/
https://www.ncbi.nlm.nih.gov/pubmed/25720391
http://dx.doi.org/10.1042/BSR20140171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400634/
https://www.ncbi.nlm.nih.gov/pubmed/25720391
http://dx.doi.org/10.1042/BSR20140171

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