PDX1 Binds and Represses Hepatic Genes to Ensure Robust Pancreatic Commitment in Differentiating Human Embryonic Stem Cells

Inactivation of the Pancreatic and Duodenal Homeobox 1 (PDX1) gene causes pancreatic agenesis, which places PDX1 high atop the regulatory network controlling development of this indispensable organ. However, little is known about the identity of PDX1 transcriptional targets. We simulated pancreatic...

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Detalles Bibliográficos
Autores principales: Teo, Adrian Kee Keong, Tsuneyoshi, Norihiro, Hoon, Shawn, Tan, Ee Kim, Stanton, Lawrence W., Wright, Christopher V.E., Dunn, N. Ray
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400640/
https://www.ncbi.nlm.nih.gov/pubmed/25843046
http://dx.doi.org/10.1016/j.stemcr.2015.02.015

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