A Novel Technique for Detecting Antibiotic-Resistant Typhoid from Rapid Diagnostic Tests

Fluoroquinolone-resistant typhoid is increasing. An antigen-detecting rapid diagnotic test (RDT) can rapidly diagnose typhoid from blood cultures. A simple, inexpensive molecular technique performed with DNA from positive RDTs accurately identified gyrA mutations consistent with phenotypic susceptib...

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Detalles Bibliográficos
Autores principales: Nic Fhogartaigh, Caoimhe, Dance, David A. B., Davong, Viengmon, Tann, Pisey, Phetsouvanh, Rattanaphone, Turner, Paul, Dittrich, Sabine, Newton, Paul N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2015
Materias:
Bacteriology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400746/
https://www.ncbi.nlm.nih.gov/pubmed/25762768
http://dx.doi.org/10.1128/JCM.00531-15
Descripción
Sumario:Fluoroquinolone-resistant typhoid is increasing. An antigen-detecting rapid diagnotic test (RDT) can rapidly diagnose typhoid from blood cultures. A simple, inexpensive molecular technique performed with DNA from positive RDTs accurately identified gyrA mutations consistent with phenotypic susceptibility testing results. Field diagnosis combined with centralized molecular resistance testing could improve typhoid management and surveillance in low-resource settings.

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