A Novel Technique for Detecting Antibiotic-Resistant Typhoid from Rapid Diagnostic Tests

Fluoroquinolone-resistant typhoid is increasing. An antigen-detecting rapid diagnotic test (RDT) can rapidly diagnose typhoid from blood cultures. A simple, inexpensive molecular technique performed with DNA from positive RDTs accurately identified gyrA mutations consistent with phenotypic susceptib...

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Autores principales: Nic Fhogartaigh, Caoimhe, Dance, David A. B., Davong, Viengmon, Tann, Pisey, Phetsouvanh, Rattanaphone, Turner, Paul, Dittrich, Sabine, Newton, Paul N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2015
Materias:
Bacteriology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400746/
https://www.ncbi.nlm.nih.gov/pubmed/25762768
http://dx.doi.org/10.1128/JCM.00531-15
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author Nic Fhogartaigh, Caoimhe
Dance, David A. B.
Davong, Viengmon
Tann, Pisey
Phetsouvanh, Rattanaphone
Turner, Paul
Dittrich, Sabine
Newton, Paul N.
author_facet Nic Fhogartaigh, Caoimhe
Dance, David A. B.
Davong, Viengmon
Tann, Pisey
Phetsouvanh, Rattanaphone
Turner, Paul
Dittrich, Sabine
Newton, Paul N.
author_sort Nic Fhogartaigh, Caoimhe
collection PubMed
description Fluoroquinolone-resistant typhoid is increasing. An antigen-detecting rapid diagnotic test (RDT) can rapidly diagnose typhoid from blood cultures. A simple, inexpensive molecular technique performed with DNA from positive RDTs accurately identified gyrA mutations consistent with phenotypic susceptibility testing results. Field diagnosis combined with centralized molecular resistance testing could improve typhoid management and surveillance in low-resource settings.
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spelling pubmed-44007462015-05-06 A Novel Technique for Detecting Antibiotic-Resistant Typhoid from Rapid Diagnostic Tests Nic Fhogartaigh, Caoimhe Dance, David A. B. Davong, Viengmon Tann, Pisey Phetsouvanh, Rattanaphone Turner, Paul Dittrich, Sabine Newton, Paul N. J Clin Microbiol Bacteriology Fluoroquinolone-resistant typhoid is increasing. An antigen-detecting rapid diagnotic test (RDT) can rapidly diagnose typhoid from blood cultures. A simple, inexpensive molecular technique performed with DNA from positive RDTs accurately identified gyrA mutations consistent with phenotypic susceptibility testing results. Field diagnosis combined with centralized molecular resistance testing could improve typhoid management and surveillance in low-resource settings. American Society for Microbiology 2015-04-16 2015-05 /pmc/articles/PMC4400746/ /pubmed/25762768 http://dx.doi.org/10.1128/JCM.00531-15 Text en Copyright © 2015, Nic Fhogartaigh et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Bacteriology
Nic Fhogartaigh, Caoimhe
Dance, David A. B.
Davong, Viengmon
Tann, Pisey
Phetsouvanh, Rattanaphone
Turner, Paul
Dittrich, Sabine
Newton, Paul N.
A Novel Technique for Detecting Antibiotic-Resistant Typhoid from Rapid Diagnostic Tests
title A Novel Technique for Detecting Antibiotic-Resistant Typhoid from Rapid Diagnostic Tests
title_full A Novel Technique for Detecting Antibiotic-Resistant Typhoid from Rapid Diagnostic Tests
title_fullStr A Novel Technique for Detecting Antibiotic-Resistant Typhoid from Rapid Diagnostic Tests
title_full_unstemmed A Novel Technique for Detecting Antibiotic-Resistant Typhoid from Rapid Diagnostic Tests
title_short A Novel Technique for Detecting Antibiotic-Resistant Typhoid from Rapid Diagnostic Tests
title_sort novel technique for detecting antibiotic-resistant typhoid from rapid diagnostic tests
topic Bacteriology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400746/
https://www.ncbi.nlm.nih.gov/pubmed/25762768
http://dx.doi.org/10.1128/JCM.00531-15
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