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Regulated Degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage

Chaperone-mediated autophagy (CMA) is activate in response to cellular stressors to prevent cellular proteotoxicity through selective degradation of altered proteins in lysosomes. Reduced CMA activity contributes to the decrease in proteome quality in disease and aging. Here, we report that CMA is a...

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Detalles Bibliográficos
Autores principales:	Park, Caroline, Suh, Yousin, Cuervo, Ana Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400843/ https://www.ncbi.nlm.nih.gov/pubmed/25880015 http://dx.doi.org/10.1038/ncomms7823

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