Identifying and applying a highly selective probe to simultaneously determine the O-glucuronidation activity of human UGT1A3 and UGT1A4

Glucuronidation mediated by uridine 5′-diphospho (UDP)-glucuronosyltransferase is an important detoxification pathway. However, identifying a selective probe of UDP- glucuronosyltransferase is complicated because of the significant overlapping substrate specificity displayed by the enzyme. In this p...

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Detalles Bibliográficos
Autores principales: Jiang, Li, Liang, Si-Cheng, Wang, Chao, Ge, Guang-Bo, Huo, Xiao-Kui, Qi, Xiao-Yi, Deng, Sa, Liu, Ke-Xin, Ma, Xiao-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401096/
https://www.ncbi.nlm.nih.gov/pubmed/25884245
http://dx.doi.org/10.1038/srep09627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401096/
https://www.ncbi.nlm.nih.gov/pubmed/25884245
http://dx.doi.org/10.1038/srep09627

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