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Brevinin-2R(1) semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway

Brevinin-2R is a novel non-hemolytic defensin that was isolated from the skin of the frog Rana ridibunda. It exhibits preferential cytotoxicity towards malignant cells, including Jurkat (T-cell leukemia), BJAB (B-cell lymphoma), HT29/219, SW742 (colon carcinomas), L929 (fibrosarcoma), MCF-7 (breast...

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Detalles Bibliográficos
Autores principales:	Ghavami, Saeid, Asoodeh, Ahmad, Klonisch, Thomas, Halayko, Andrew J, Kadkhoda, Kamran, Kroczak, Tadeusz J, Gibson, Spencer B, Booy, Evan P, Naderi-Manesh, Hossein, Los, Marek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2008
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401144/ https://www.ncbi.nlm.nih.gov/pubmed/18494941 http://dx.doi.org/10.1111/j.1582-4934.2008.00129.x

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