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Prognostic significance of neutrophil-to- lymphocyte ratio in esophageal cancer: a meta-analysis

BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) is a useful predictive factor in several cancers. However, the prognostic value of NLR in patients with esophageal cancer (EC) is still controversial. Therefore, it was necessary for us to perform a meta-analysis to evaluate the prognostic value o...

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Autores principales: Yang, Xun, Huang, Ying, Feng, Ji-Feng, Liu, Jin-Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401207/
https://www.ncbi.nlm.nih.gov/pubmed/25914549
http://dx.doi.org/10.2147/OTT.S77099
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author Yang, Xun
Huang, Ying
Feng, Ji-Feng
Liu, Jin-Shi
author_facet Yang, Xun
Huang, Ying
Feng, Ji-Feng
Liu, Jin-Shi
author_sort Yang, Xun
collection PubMed
description BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) is a useful predictive factor in several cancers. However, the prognostic value of NLR in patients with esophageal cancer (EC) is still controversial. Therefore, it was necessary for us to perform a meta-analysis to evaluate the prognostic value of NLR in patients with EC. METHODS: A systematic literature search was performed by using Web of Science, PubMed Central, and Medline to evaluate the prognostic value of NLR in patients with EC. The deadline of our primary search was July 10, 2014. This meta-analysis was conducted in accordance with PRISMA guidelines. Pooled hazard ratio (HR) with 95% confidence interval (CI) was used to assess the association of NLR and overall survival (OS) and disease-free survival (DFS). RESULTS: Six studies involving 1,633 patients were included in our meta-analysis. Our pooled results demonstrated that high NLR was associated with poor OS (HR: 1.54, 95% CI: 1.32–1.80, I 2=25.3%, P=0.254) and DFS (HR: 1.74, 95% CI: 1.25–2.43, I 2=63.9%, P=0.096). Subgroup analysis between NLR and OS was performed in a further investigation. When the patients were segregated according to country, sample size, and pathological type, high NLR was also significantly correlated with OS. CONCLUSION: High NLR is associated with poor prognosis in patients with EC. NLR may be a significant predictive biomarker in patients with EC.
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spelling pubmed-44012072015-04-24 Prognostic significance of neutrophil-to- lymphocyte ratio in esophageal cancer: a meta-analysis Yang, Xun Huang, Ying Feng, Ji-Feng Liu, Jin-Shi Onco Targets Ther Original Research BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) is a useful predictive factor in several cancers. However, the prognostic value of NLR in patients with esophageal cancer (EC) is still controversial. Therefore, it was necessary for us to perform a meta-analysis to evaluate the prognostic value of NLR in patients with EC. METHODS: A systematic literature search was performed by using Web of Science, PubMed Central, and Medline to evaluate the prognostic value of NLR in patients with EC. The deadline of our primary search was July 10, 2014. This meta-analysis was conducted in accordance with PRISMA guidelines. Pooled hazard ratio (HR) with 95% confidence interval (CI) was used to assess the association of NLR and overall survival (OS) and disease-free survival (DFS). RESULTS: Six studies involving 1,633 patients were included in our meta-analysis. Our pooled results demonstrated that high NLR was associated with poor OS (HR: 1.54, 95% CI: 1.32–1.80, I 2=25.3%, P=0.254) and DFS (HR: 1.74, 95% CI: 1.25–2.43, I 2=63.9%, P=0.096). Subgroup analysis between NLR and OS was performed in a further investigation. When the patients were segregated according to country, sample size, and pathological type, high NLR was also significantly correlated with OS. CONCLUSION: High NLR is associated with poor prognosis in patients with EC. NLR may be a significant predictive biomarker in patients with EC. Dove Medical Press 2015-04-10 /pmc/articles/PMC4401207/ /pubmed/25914549 http://dx.doi.org/10.2147/OTT.S77099 Text en © 2015 Yang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Yang, Xun
Huang, Ying
Feng, Ji-Feng
Liu, Jin-Shi
Prognostic significance of neutrophil-to- lymphocyte ratio in esophageal cancer: a meta-analysis
title Prognostic significance of neutrophil-to- lymphocyte ratio in esophageal cancer: a meta-analysis
title_full Prognostic significance of neutrophil-to- lymphocyte ratio in esophageal cancer: a meta-analysis
title_fullStr Prognostic significance of neutrophil-to- lymphocyte ratio in esophageal cancer: a meta-analysis
title_full_unstemmed Prognostic significance of neutrophil-to- lymphocyte ratio in esophageal cancer: a meta-analysis
title_short Prognostic significance of neutrophil-to- lymphocyte ratio in esophageal cancer: a meta-analysis
title_sort prognostic significance of neutrophil-to- lymphocyte ratio in esophageal cancer: a meta-analysis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401207/
https://www.ncbi.nlm.nih.gov/pubmed/25914549
http://dx.doi.org/10.2147/OTT.S77099
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