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Prognostic significance of neutrophil-to- lymphocyte ratio in esophageal cancer: a meta-analysis
BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) is a useful predictive factor in several cancers. However, the prognostic value of NLR in patients with esophageal cancer (EC) is still controversial. Therefore, it was necessary for us to perform a meta-analysis to evaluate the prognostic value o...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401207/ https://www.ncbi.nlm.nih.gov/pubmed/25914549 http://dx.doi.org/10.2147/OTT.S77099 |
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author | Yang, Xun Huang, Ying Feng, Ji-Feng Liu, Jin-Shi |
author_facet | Yang, Xun Huang, Ying Feng, Ji-Feng Liu, Jin-Shi |
author_sort | Yang, Xun |
collection | PubMed |
description | BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) is a useful predictive factor in several cancers. However, the prognostic value of NLR in patients with esophageal cancer (EC) is still controversial. Therefore, it was necessary for us to perform a meta-analysis to evaluate the prognostic value of NLR in patients with EC. METHODS: A systematic literature search was performed by using Web of Science, PubMed Central, and Medline to evaluate the prognostic value of NLR in patients with EC. The deadline of our primary search was July 10, 2014. This meta-analysis was conducted in accordance with PRISMA guidelines. Pooled hazard ratio (HR) with 95% confidence interval (CI) was used to assess the association of NLR and overall survival (OS) and disease-free survival (DFS). RESULTS: Six studies involving 1,633 patients were included in our meta-analysis. Our pooled results demonstrated that high NLR was associated with poor OS (HR: 1.54, 95% CI: 1.32–1.80, I 2=25.3%, P=0.254) and DFS (HR: 1.74, 95% CI: 1.25–2.43, I 2=63.9%, P=0.096). Subgroup analysis between NLR and OS was performed in a further investigation. When the patients were segregated according to country, sample size, and pathological type, high NLR was also significantly correlated with OS. CONCLUSION: High NLR is associated with poor prognosis in patients with EC. NLR may be a significant predictive biomarker in patients with EC. |
format | Online Article Text |
id | pubmed-4401207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-44012072015-04-24 Prognostic significance of neutrophil-to- lymphocyte ratio in esophageal cancer: a meta-analysis Yang, Xun Huang, Ying Feng, Ji-Feng Liu, Jin-Shi Onco Targets Ther Original Research BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) is a useful predictive factor in several cancers. However, the prognostic value of NLR in patients with esophageal cancer (EC) is still controversial. Therefore, it was necessary for us to perform a meta-analysis to evaluate the prognostic value of NLR in patients with EC. METHODS: A systematic literature search was performed by using Web of Science, PubMed Central, and Medline to evaluate the prognostic value of NLR in patients with EC. The deadline of our primary search was July 10, 2014. This meta-analysis was conducted in accordance with PRISMA guidelines. Pooled hazard ratio (HR) with 95% confidence interval (CI) was used to assess the association of NLR and overall survival (OS) and disease-free survival (DFS). RESULTS: Six studies involving 1,633 patients were included in our meta-analysis. Our pooled results demonstrated that high NLR was associated with poor OS (HR: 1.54, 95% CI: 1.32–1.80, I 2=25.3%, P=0.254) and DFS (HR: 1.74, 95% CI: 1.25–2.43, I 2=63.9%, P=0.096). Subgroup analysis between NLR and OS was performed in a further investigation. When the patients were segregated according to country, sample size, and pathological type, high NLR was also significantly correlated with OS. CONCLUSION: High NLR is associated with poor prognosis in patients with EC. NLR may be a significant predictive biomarker in patients with EC. Dove Medical Press 2015-04-10 /pmc/articles/PMC4401207/ /pubmed/25914549 http://dx.doi.org/10.2147/OTT.S77099 Text en © 2015 Yang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Yang, Xun Huang, Ying Feng, Ji-Feng Liu, Jin-Shi Prognostic significance of neutrophil-to- lymphocyte ratio in esophageal cancer: a meta-analysis |
title | Prognostic significance of neutrophil-to- lymphocyte ratio in esophageal cancer: a meta-analysis |
title_full | Prognostic significance of neutrophil-to- lymphocyte ratio in esophageal cancer: a meta-analysis |
title_fullStr | Prognostic significance of neutrophil-to- lymphocyte ratio in esophageal cancer: a meta-analysis |
title_full_unstemmed | Prognostic significance of neutrophil-to- lymphocyte ratio in esophageal cancer: a meta-analysis |
title_short | Prognostic significance of neutrophil-to- lymphocyte ratio in esophageal cancer: a meta-analysis |
title_sort | prognostic significance of neutrophil-to- lymphocyte ratio in esophageal cancer: a meta-analysis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401207/ https://www.ncbi.nlm.nih.gov/pubmed/25914549 http://dx.doi.org/10.2147/OTT.S77099 |
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