Toll-like receptor 4 in atherosclerosis

Toll-like receptor 4 (TLR4) is key regulators of both innate and adaptive immune responses. TLR4 recognizes pathogen-associated molecular patterns (PAMPs) and activates the inflammatory cells. The function of TLR4 in atherosclerosis has been investigated in mouse knockout studies and epidemiological...

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Detalles Bibliográficos
Autores principales: Li, Hongli, Sun, Baogui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2007
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401222/
https://www.ncbi.nlm.nih.gov/pubmed/17367503
http://dx.doi.org/10.1111/j.1582-4934.2007.00011.x
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author Li, Hongli
Sun, Baogui
author_facet Li, Hongli
Sun, Baogui
author_sort Li, Hongli
collection PubMed
description Toll-like receptor 4 (TLR4) is key regulators of both innate and adaptive immune responses. TLR4 recognizes pathogen-associated molecular patterns (PAMPs) and activates the inflammatory cells. The function of TLR4 in atherosclerosis has been investigated in mouse knockout studies and epidemiological studies of human TLR4 polymorphisms. These studies have shown that TLR4 function affects the initiation and progression of atherosclerosis. This article reviews the biological functions and clinical implications of TLR4 in atherosclerosis.
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spelling pubmed-44012222015-04-27 Toll-like receptor 4 in atherosclerosis Li, Hongli Sun, Baogui J Cell Mol Med Reviews Toll-like receptor 4 (TLR4) is key regulators of both innate and adaptive immune responses. TLR4 recognizes pathogen-associated molecular patterns (PAMPs) and activates the inflammatory cells. The function of TLR4 in atherosclerosis has been investigated in mouse knockout studies and epidemiological studies of human TLR4 polymorphisms. These studies have shown that TLR4 function affects the initiation and progression of atherosclerosis. This article reviews the biological functions and clinical implications of TLR4 in atherosclerosis. Blackwell Publishing Ltd 2007-01 2007-03-15 /pmc/articles/PMC4401222/ /pubmed/17367503 http://dx.doi.org/10.1111/j.1582-4934.2007.00011.x Text en
spellingShingle Reviews
Li, Hongli
Sun, Baogui
Toll-like receptor 4 in atherosclerosis
title Toll-like receptor 4 in atherosclerosis
title_full Toll-like receptor 4 in atherosclerosis
title_fullStr Toll-like receptor 4 in atherosclerosis
title_full_unstemmed Toll-like receptor 4 in atherosclerosis
title_short Toll-like receptor 4 in atherosclerosis
title_sort toll-like receptor 4 in atherosclerosis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401222/
https://www.ncbi.nlm.nih.gov/pubmed/17367503
http://dx.doi.org/10.1111/j.1582-4934.2007.00011.x
work_keys_str_mv AT lihongli tolllikereceptor4inatherosclerosis
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