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An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences

Purine bias, which is usually referred to as an “ancestral codon”, is known to result in short-range correlations between nucleotides in coding sequences, and it is common in all species. We demonstrate that RWY is a more appropriate pattern than the classical RNY, and purine bias (Rrr) is the produ...

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Autores principales: Carels, Nicolas, de Leon, Miguel Ponce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401237/
https://www.ncbi.nlm.nih.gov/pubmed/25922573
http://dx.doi.org/10.4137/BBI.S24021
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author Carels, Nicolas
de Leon, Miguel Ponce
author_facet Carels, Nicolas
de Leon, Miguel Ponce
author_sort Carels, Nicolas
collection PubMed
description Purine bias, which is usually referred to as an “ancestral codon”, is known to result in short-range correlations between nucleotides in coding sequences, and it is common in all species. We demonstrate that RWY is a more appropriate pattern than the classical RNY, and purine bias (Rrr) is the product of a network of nucleotide compensations induced by functional constraints on the physicochemical properties of proteins. Through deductions from universal correlation properties, we also demonstrate that amino acids from Miller’s spark discharge experiment are compatible with functional primeval proteins at the dawn of living cell radiation on earth. These amino acids match the hydropathy and secondary structures of modern proteins.
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spelling pubmed-44012372015-04-28 An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences Carels, Nicolas de Leon, Miguel Ponce Bioinform Biol Insights Original Research Purine bias, which is usually referred to as an “ancestral codon”, is known to result in short-range correlations between nucleotides in coding sequences, and it is common in all species. We demonstrate that RWY is a more appropriate pattern than the classical RNY, and purine bias (Rrr) is the product of a network of nucleotide compensations induced by functional constraints on the physicochemical properties of proteins. Through deductions from universal correlation properties, we also demonstrate that amino acids from Miller’s spark discharge experiment are compatible with functional primeval proteins at the dawn of living cell radiation on earth. These amino acids match the hydropathy and secondary structures of modern proteins. Libertas Academica 2015-04-15 /pmc/articles/PMC4401237/ /pubmed/25922573 http://dx.doi.org/10.4137/BBI.S24021 Text en © 2015 the authors, publisher and licensee Libertas Academica Limited. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Original Research
Carels, Nicolas
de Leon, Miguel Ponce
An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences
title An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences
title_full An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences
title_fullStr An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences
title_full_unstemmed An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences
title_short An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences
title_sort interpretation of the ancestral codon from miller’s amino acids and nucleotide correlations in modern coding sequences
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401237/
https://www.ncbi.nlm.nih.gov/pubmed/25922573
http://dx.doi.org/10.4137/BBI.S24021
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