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Stem cell and kinase activity-independent pathway in resistance of leukaemia to BCR-ABL kinase inhibitors
BCR-ABL tyrosine kinase inhibitors, such as imatinib (Gleevec) are highly effective in treating human Philadelphia chromosome-positive (Ph(+)) chronic myeloid leukaemia (CML) in chronic phase but not in terminal acute phase; acquired drug resistance caused mainly by the development of BCR-ABL kinase...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Blackwell Publishing Ltd
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401291/ https://www.ncbi.nlm.nih.gov/pubmed/18205699 http://dx.doi.org/10.1111/j.1582-4934.2007.00108.x |