Covalent Modification of the Mycobacterium tuberculosis FAS-II Dehydratase by Isoxyl and Thiacetazone

[Image: see text] Isoxyl (ISO) and thiacetazone (TAC) are two antitubercular prodrugs formerly used in the clinical treatment of tuberculosis. Although both prodrugs have recently been shown to kill Mycobacterium tuberculosis through the inhibition of the dehydration step of the type II fatty acid s...

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Detalles Bibliográficos
Autores principales: Grzegorzewicz, Anna E., Eynard, Nathalie, Quémard, Annaïk, North, E. Jeffrey, Margolis, Alyssa, Lindenberger, Jared J., Jones, Victoria, Korduláková, Jana, Brennan, Patrick J., Lee, Richard E., Ronning, Donald R., McNeil, Michael R., Jackson, Mary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401429/
https://www.ncbi.nlm.nih.gov/pubmed/25897434
http://dx.doi.org/10.1021/id500032q

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401429/
https://www.ncbi.nlm.nih.gov/pubmed/25897434
http://dx.doi.org/10.1021/id500032q

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