Anti-Yo Antibody Uptake and Interaction with Its Intracellular Target Antigen Causes Purkinje Cell Death in Rat Cerebellar Slice Cultures: A Possible Mechanism for Paraneoplastic Cerebellar Degeneration in Humans with Gynecological or Breast Cancers

Anti-Yo antibodies are immunoglobulin G (IgG) autoantibodies reactive with a 62 kDa Purkinje cell cytoplasmic protein. These antibodies are closely associated with paraneoplastic cerebellar degeneration in the setting of gynecological and breast malignancies. We have previously demonstrated that inc...

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Detalles Bibliográficos
Autores principales: Greenlee, John E., Clawson, Susan A., Hill, Kenneth E., Wood, Blair, Clardy, Stacey L., Tsunoda, Ikuo, Carlson, Noel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401511/
https://www.ncbi.nlm.nih.gov/pubmed/25885452
http://dx.doi.org/10.1371/journal.pone.0123446

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