Structure- and Ligand-Based Virtual Screening Identifies New Scaffolds for Inhibitors of the Oncoprotein MDM2

A major challenge in the field of ligand discovery is to identify chemically useful fragments that can be developed into inhibitors of specific protein-protein interactions. Low molecular weight fragments (with molecular weight less than 250 Da) are likely to bind weakly to a protein’s surface. Here...

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Detalles Bibliográficos
Autores principales: Houston, Douglas R., Yen, Li-Hsuan, Pettit, Simon, Walkinshaw, Malcolm D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401541/
https://www.ncbi.nlm.nih.gov/pubmed/25884407
http://dx.doi.org/10.1371/journal.pone.0121424

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