Aminotriazole Alleviates Acetaminophen Poisoning via Downregulating P450 2E1 and Suppressing Inflammation

Aminotriazole (ATZ) is commonly used as a catalase (CAT) inhibitor. We previously found ATZ attenuated oxidative liver injury, but the underlying mechanisms remain unknown. Acetaminophen (APAP) overdose frequently induces life-threatening oxidative hepatitis. In the present study, the potential hepa...

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Detalles Bibliográficos
Autores principales: Jing, Yuping, Wu, Kunwei, Liu, Jiashuo, Ai, Qing, Ge, Pu, Dai, Jie, Jiang, Rong, Zhou, Dan, Che, Qian, Wan, Jingyuan, Zhang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401561/
https://www.ncbi.nlm.nih.gov/pubmed/25884831
http://dx.doi.org/10.1371/journal.pone.0122781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401561/
https://www.ncbi.nlm.nih.gov/pubmed/25884831
http://dx.doi.org/10.1371/journal.pone.0122781

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