Radiation and Dual Checkpoint Blockade Activates Non-Redundant Immune Mechanisms in Cancer

Immune checkpoint inhibitors(1) result in impressive clinical responses(2–5) but optimal results will require combination with each other(6) and other therapies. This raises fundamental questions about mechanisms of non-redundancy and resistance. Here, we report major tumor regressions in a subset o...

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Detalles Bibliográficos
Autores principales: Victor, Christina Twyman-Saint, Rech, Andrew J., Maity, Amit, Rengan, Ramesh, Pauken, Kristen E., Stelekati, Erietta, Benci, Joseph L., Xu, Bihui, Dada, Hannah, Odorizzi, Pamela M., Herati, Ramin S., Mansfield, Kathleen D., Patsch, Dana, Amaravadi, Ravi K., Schuchter, Lynn M., Ishwaran, Hemant, Mick, Rosemarie, Pryma, Daniel A., Xu, Xiaowei, Feldman, Michael D., Gangadhar, Tara C., Hahn, Stephen M., Wherry, E. John, Vonderheide, Robert H., Minn, Andy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401634/
https://www.ncbi.nlm.nih.gov/pubmed/25754329
http://dx.doi.org/10.1038/nature14292

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