Cargando…
Renal Denervation Suppresses Atrial Fibrillation in a Model of Renal Impairment
BACKGROUND: A close association exists between renal impairment (RI) and atrial fibrillation (AF) occurrence. Increased activity of the sympathetic nervous system (SNS) may contribute to the development of AF associated with RI. Renal denervation (RDN) decreases central sympathetic activity. OBJECTI...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401704/ https://www.ncbi.nlm.nih.gov/pubmed/25884946 http://dx.doi.org/10.1371/journal.pone.0124123 |
_version_ | 1782367177272197120 |
---|---|
author | Liang, Zhuo Shi, Xiang-min Liu, Li-feng Chen, Xin-pei Shan, Zhao-liang Lin, Kun Li, Jian Chen, Fu-kun Li, Yan-guang Guo, Hong-yang Wang, Yu-tang |
author_facet | Liang, Zhuo Shi, Xiang-min Liu, Li-feng Chen, Xin-pei Shan, Zhao-liang Lin, Kun Li, Jian Chen, Fu-kun Li, Yan-guang Guo, Hong-yang Wang, Yu-tang |
author_sort | Liang, Zhuo |
collection | PubMed |
description | BACKGROUND: A close association exists between renal impairment (RI) and atrial fibrillation (AF) occurrence. Increased activity of the sympathetic nervous system (SNS) may contribute to the development of AF associated with RI. Renal denervation (RDN) decreases central sympathetic activity. OBJECTIVE: The main objective of the study was to explore the effects of RDN on AF occurrence and its possible mechanisms in beagles with RI. METHODS: Unilateral RI was induced in beagles by embolization of small branches of the renal artery in the right kidney using gelatin sponge granules in Model (n = 6) and RDN group (n = 6). The Sham group (n = 6) underwent the same procedure, except for embolization. Then animals in RDN group underwent radiofrequency ablation of the renal sympathetic nerve. Cardiac electrophysiological parameters, blood pressure, left ventricular end-diastolic pressure, and AF inducibility were investigated. The activity of the SNS, renin-angiotensin-aldosterone system (RAAS), inflammation and atrial interstitial fibrosis were measured. RESULTS: Embolization of small branches of the renal artery in the right kidney led to ischemic RI. Heart rate, P wave duration and BP were increased by RI, which were prevented or attenuated by RDN. Atrial effective refractory period was shortened and AF inducibility was increased by RI, which were prevented by RDN. Antegrade Wenckebach point was shortened, atrial and ventricular rates during AF were increased by RI, which were attenuated or prevented by RDN. Levels of norepinephrine, renin and aldosterone in plasma, norepinephrine, angiotensin II, aldosterone, interleukin-6 and high sensitivity C-reactive protein in atrial tissue were elevated, and atrial interstitial fibrosis was enhanced by RI, which were attenuated by RDN. CONCLUSIONS: RDN significantly reduced AF inducibility, prevented the atrial electrophysiological changes in a model of RI by combined reduction of sympathetic drive and RAAS activity, and inhibition of inflammation activity and fibrotic pathway in atrial tissue. |
format | Online Article Text |
id | pubmed-4401704 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-44017042015-04-21 Renal Denervation Suppresses Atrial Fibrillation in a Model of Renal Impairment Liang, Zhuo Shi, Xiang-min Liu, Li-feng Chen, Xin-pei Shan, Zhao-liang Lin, Kun Li, Jian Chen, Fu-kun Li, Yan-guang Guo, Hong-yang Wang, Yu-tang PLoS One Research Article BACKGROUND: A close association exists between renal impairment (RI) and atrial fibrillation (AF) occurrence. Increased activity of the sympathetic nervous system (SNS) may contribute to the development of AF associated with RI. Renal denervation (RDN) decreases central sympathetic activity. OBJECTIVE: The main objective of the study was to explore the effects of RDN on AF occurrence and its possible mechanisms in beagles with RI. METHODS: Unilateral RI was induced in beagles by embolization of small branches of the renal artery in the right kidney using gelatin sponge granules in Model (n = 6) and RDN group (n = 6). The Sham group (n = 6) underwent the same procedure, except for embolization. Then animals in RDN group underwent radiofrequency ablation of the renal sympathetic nerve. Cardiac electrophysiological parameters, blood pressure, left ventricular end-diastolic pressure, and AF inducibility were investigated. The activity of the SNS, renin-angiotensin-aldosterone system (RAAS), inflammation and atrial interstitial fibrosis were measured. RESULTS: Embolization of small branches of the renal artery in the right kidney led to ischemic RI. Heart rate, P wave duration and BP were increased by RI, which were prevented or attenuated by RDN. Atrial effective refractory period was shortened and AF inducibility was increased by RI, which were prevented by RDN. Antegrade Wenckebach point was shortened, atrial and ventricular rates during AF were increased by RI, which were attenuated or prevented by RDN. Levels of norepinephrine, renin and aldosterone in plasma, norepinephrine, angiotensin II, aldosterone, interleukin-6 and high sensitivity C-reactive protein in atrial tissue were elevated, and atrial interstitial fibrosis was enhanced by RI, which were attenuated by RDN. CONCLUSIONS: RDN significantly reduced AF inducibility, prevented the atrial electrophysiological changes in a model of RI by combined reduction of sympathetic drive and RAAS activity, and inhibition of inflammation activity and fibrotic pathway in atrial tissue. Public Library of Science 2015-04-17 /pmc/articles/PMC4401704/ /pubmed/25884946 http://dx.doi.org/10.1371/journal.pone.0124123 Text en © 2015 Liang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Liang, Zhuo Shi, Xiang-min Liu, Li-feng Chen, Xin-pei Shan, Zhao-liang Lin, Kun Li, Jian Chen, Fu-kun Li, Yan-guang Guo, Hong-yang Wang, Yu-tang Renal Denervation Suppresses Atrial Fibrillation in a Model of Renal Impairment |
title | Renal Denervation Suppresses Atrial Fibrillation in a Model of Renal Impairment |
title_full | Renal Denervation Suppresses Atrial Fibrillation in a Model of Renal Impairment |
title_fullStr | Renal Denervation Suppresses Atrial Fibrillation in a Model of Renal Impairment |
title_full_unstemmed | Renal Denervation Suppresses Atrial Fibrillation in a Model of Renal Impairment |
title_short | Renal Denervation Suppresses Atrial Fibrillation in a Model of Renal Impairment |
title_sort | renal denervation suppresses atrial fibrillation in a model of renal impairment |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401704/ https://www.ncbi.nlm.nih.gov/pubmed/25884946 http://dx.doi.org/10.1371/journal.pone.0124123 |
work_keys_str_mv | AT liangzhuo renaldenervationsuppressesatrialfibrillationinamodelofrenalimpairment AT shixiangmin renaldenervationsuppressesatrialfibrillationinamodelofrenalimpairment AT liulifeng renaldenervationsuppressesatrialfibrillationinamodelofrenalimpairment AT chenxinpei renaldenervationsuppressesatrialfibrillationinamodelofrenalimpairment AT shanzhaoliang renaldenervationsuppressesatrialfibrillationinamodelofrenalimpairment AT linkun renaldenervationsuppressesatrialfibrillationinamodelofrenalimpairment AT lijian renaldenervationsuppressesatrialfibrillationinamodelofrenalimpairment AT chenfukun renaldenervationsuppressesatrialfibrillationinamodelofrenalimpairment AT liyanguang renaldenervationsuppressesatrialfibrillationinamodelofrenalimpairment AT guohongyang renaldenervationsuppressesatrialfibrillationinamodelofrenalimpairment AT wangyutang renaldenervationsuppressesatrialfibrillationinamodelofrenalimpairment |