The Rab2A GTPase Promotes Breast Cancer Stem Cells and Tumorigenesis via Erk Signaling Activation

Proline-directed phosphorylation is regulated by the prolyl isomerase Pin1, which plays a fundamental role in driving breast cancer stem-like cells (BCSCs). Rab2A is a small GTPase critical for vesicle trafficking. Here, we show that Pin1 increases Rab2A transcription to promote BCSC expansion and t...

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Detalles Bibliográficos
Autores principales: Luo, Man-Li, Gong, Chang, Chen, Chun-Hau, Hu, Hai, Huang, Pengyu, Zheng, Min, Yao, Yandan, Wei, Shuo, Wulf, Gerburg, Lieberman, Judy, Zhou, Xiao Zhen, Song, Erwei, Lu, Kun Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401741/
https://www.ncbi.nlm.nih.gov/pubmed/25818297
http://dx.doi.org/10.1016/j.celrep.2015.03.002

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