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Effect of glucomannan supplementation on body weight in overweight and obese children: protocol of a randomised controlled trial
INTRODUCTION: Glucomannan (GNN), a water-soluble dietary fibre derived from the plant Amorphophallus konjac, is marketed for weight reduction. The exact mechanisms by which GNN might exert its actions are unclear. However, it has been shown that GNN slows gastric emptying by forming a viscous gel of...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401854/ https://www.ncbi.nlm.nih.gov/pubmed/25869689 http://dx.doi.org/10.1136/bmjopen-2014-007244 |
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author | Zalewski, Bartłomiej Mateusz Szajewska, Hania |
author_facet | Zalewski, Bartłomiej Mateusz Szajewska, Hania |
author_sort | Zalewski, Bartłomiej Mateusz |
collection | PubMed |
description | INTRODUCTION: Glucomannan (GNN), a water-soluble dietary fibre derived from the plant Amorphophallus konjac, is marketed for weight reduction. The exact mechanisms by which GNN might exert its actions are unclear. However, it has been shown that GNN slows gastric emptying by forming a viscous gel of large volume, which increases the feeling of satiety. Current evidence on the effectiveness of GNN for weight reduction is sparse, and well-designed trials performed in children are needed to assess the efficacy of this modality. We aim to systematically evaluate the efficacy of GNN consumption for the management of children who are overweight or obese. METHODS AND ANALYSIS: Children aged 6–17 years who are overweight or obese (based on the WHO growth criteria) will be randomly assigned to receive GNN or placebo (maltodextrin) (both at a dose of 3 g/day) for 3 months and will be followed-up for 3 months. Before the intervention, all children will receive dietetic advice, and they will be encouraged to engage in physical activity. The primary outcome measure will be the body mass index-for-age z-score difference between the groups at the end of the intervention. ETHICS AND DISSEMINATION: The study was approved by the Bioethics Committee of the Medical University of Warsaw. The findings of this trial will be submitted to a peer-reviewed journal (paediatric, nutrition or gastroenterology). Abstracts will be submitted to relevant national and international conferences. TRIAL REGISTRATION NUMBER: NCT02280772. |
format | Online Article Text |
id | pubmed-4401854 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-44018542015-04-29 Effect of glucomannan supplementation on body weight in overweight and obese children: protocol of a randomised controlled trial Zalewski, Bartłomiej Mateusz Szajewska, Hania BMJ Open Paediatrics INTRODUCTION: Glucomannan (GNN), a water-soluble dietary fibre derived from the plant Amorphophallus konjac, is marketed for weight reduction. The exact mechanisms by which GNN might exert its actions are unclear. However, it has been shown that GNN slows gastric emptying by forming a viscous gel of large volume, which increases the feeling of satiety. Current evidence on the effectiveness of GNN for weight reduction is sparse, and well-designed trials performed in children are needed to assess the efficacy of this modality. We aim to systematically evaluate the efficacy of GNN consumption for the management of children who are overweight or obese. METHODS AND ANALYSIS: Children aged 6–17 years who are overweight or obese (based on the WHO growth criteria) will be randomly assigned to receive GNN or placebo (maltodextrin) (both at a dose of 3 g/day) for 3 months and will be followed-up for 3 months. Before the intervention, all children will receive dietetic advice, and they will be encouraged to engage in physical activity. The primary outcome measure will be the body mass index-for-age z-score difference between the groups at the end of the intervention. ETHICS AND DISSEMINATION: The study was approved by the Bioethics Committee of the Medical University of Warsaw. The findings of this trial will be submitted to a peer-reviewed journal (paediatric, nutrition or gastroenterology). Abstracts will be submitted to relevant national and international conferences. TRIAL REGISTRATION NUMBER: NCT02280772. BMJ Publishing Group 2015-04-13 /pmc/articles/PMC4401854/ /pubmed/25869689 http://dx.doi.org/10.1136/bmjopen-2014-007244 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Paediatrics Zalewski, Bartłomiej Mateusz Szajewska, Hania Effect of glucomannan supplementation on body weight in overweight and obese children: protocol of a randomised controlled trial |
title | Effect of glucomannan supplementation on body weight in overweight and obese children: protocol of a randomised controlled trial |
title_full | Effect of glucomannan supplementation on body weight in overweight and obese children: protocol of a randomised controlled trial |
title_fullStr | Effect of glucomannan supplementation on body weight in overweight and obese children: protocol of a randomised controlled trial |
title_full_unstemmed | Effect of glucomannan supplementation on body weight in overweight and obese children: protocol of a randomised controlled trial |
title_short | Effect of glucomannan supplementation on body weight in overweight and obese children: protocol of a randomised controlled trial |
title_sort | effect of glucomannan supplementation on body weight in overweight and obese children: protocol of a randomised controlled trial |
topic | Paediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401854/ https://www.ncbi.nlm.nih.gov/pubmed/25869689 http://dx.doi.org/10.1136/bmjopen-2014-007244 |
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