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Musical tasks targeting preserved and impaired functions in two dementias

Studies of musical abilities in dementia have for the most part been rather general assessments of abilities, for instance, assessing retention of music learned premorbidly. Here, we studied patients with dementias with contrasting cognitive profiles to explore specific aspects of music cognition un...

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Autores principales: Halpern, Andrea R, Golden, Hannah L, Magdalinou, Nadia, Witoonpanich, Pirada, Warren, Jason D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401999/
https://www.ncbi.nlm.nih.gov/pubmed/25773640
http://dx.doi.org/10.1111/nyas.12616
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author Halpern, Andrea R
Golden, Hannah L
Magdalinou, Nadia
Witoonpanich, Pirada
Warren, Jason D
author_facet Halpern, Andrea R
Golden, Hannah L
Magdalinou, Nadia
Witoonpanich, Pirada
Warren, Jason D
author_sort Halpern, Andrea R
collection PubMed
description Studies of musical abilities in dementia have for the most part been rather general assessments of abilities, for instance, assessing retention of music learned premorbidly. Here, we studied patients with dementias with contrasting cognitive profiles to explore specific aspects of music cognition under challenge. Patients suffered from Alzheimer's disease (AD), in which a primary impairment is in forming new declarative memories, or Lewy body disease (PD/LBD), a type of parkinsonism in which executive impairments are prominent. In the AD patients, we examined musical imagery. Behavioral and neural evidence confirms involvement of perceptual networks in imagery, and these are relatively spared in early stages of the illness. Thus, we expected patients to have relatively intact imagery in a mental pitch comparison task. For the LBD patients, we tested whether executive dysfunction would extend to music. We probed inhibitory skills by asking for a speeded pitch or timbre judgment when the irrelevant dimension was held constant or also changed. Preliminary results show that AD patients score similarly to controls in the imagery tasks, but PD/LBD patients are impaired relative to controls in suppressing some irrelevant musical dimensions, particularly when the required judgment varies from trial to trial.
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spelling pubmed-44019992015-04-22 Musical tasks targeting preserved and impaired functions in two dementias Halpern, Andrea R Golden, Hannah L Magdalinou, Nadia Witoonpanich, Pirada Warren, Jason D Ann N Y Acad Sci Original Articles Studies of musical abilities in dementia have for the most part been rather general assessments of abilities, for instance, assessing retention of music learned premorbidly. Here, we studied patients with dementias with contrasting cognitive profiles to explore specific aspects of music cognition under challenge. Patients suffered from Alzheimer's disease (AD), in which a primary impairment is in forming new declarative memories, or Lewy body disease (PD/LBD), a type of parkinsonism in which executive impairments are prominent. In the AD patients, we examined musical imagery. Behavioral and neural evidence confirms involvement of perceptual networks in imagery, and these are relatively spared in early stages of the illness. Thus, we expected patients to have relatively intact imagery in a mental pitch comparison task. For the LBD patients, we tested whether executive dysfunction would extend to music. We probed inhibitory skills by asking for a speeded pitch or timbre judgment when the irrelevant dimension was held constant or also changed. Preliminary results show that AD patients score similarly to controls in the imagery tasks, but PD/LBD patients are impaired relative to controls in suppressing some irrelevant musical dimensions, particularly when the required judgment varies from trial to trial. BlackWell Publishing Ltd 2015-03 2015-03-13 /pmc/articles/PMC4401999/ /pubmed/25773640 http://dx.doi.org/10.1111/nyas.12616 Text en © 2014 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals Inc. on behalf of The New York Academy of Sciences. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Halpern, Andrea R
Golden, Hannah L
Magdalinou, Nadia
Witoonpanich, Pirada
Warren, Jason D
Musical tasks targeting preserved and impaired functions in two dementias
title Musical tasks targeting preserved and impaired functions in two dementias
title_full Musical tasks targeting preserved and impaired functions in two dementias
title_fullStr Musical tasks targeting preserved and impaired functions in two dementias
title_full_unstemmed Musical tasks targeting preserved and impaired functions in two dementias
title_short Musical tasks targeting preserved and impaired functions in two dementias
title_sort musical tasks targeting preserved and impaired functions in two dementias
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401999/
https://www.ncbi.nlm.nih.gov/pubmed/25773640
http://dx.doi.org/10.1111/nyas.12616
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