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Small Molecule-Triggered Cas9 Protein with Improved Genome-Editing Specificity
Directly modulating the activity of genome-editing proteins has the potential to increase their specificity by reducing activity following target locus modification. We developed Cas9 nucleases that are activated by the presence of a cell-permeable small molecule by inserting an evolved 4-hydroxytam...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402137/ https://www.ncbi.nlm.nih.gov/pubmed/25848930 http://dx.doi.org/10.1038/nchembio.1793 |