Predicting a double mutant in the twilight zone of low homology modeling for the skeletal muscle voltage-gated sodium channel subunit beta-1 (Na(v)1.4 β1)

The molecular structure modeling of the β1 subunit of the skeletal muscle voltage-gated sodium channel (Na(v)1.4) was carried out in the twilight zone of very low homology. Structural significance can per se be confounded with random sequence similarities. Hence, we combined (i) not automated comput...

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Detalles Bibliográficos
Autores principales: Scior, Thomas, Paiz-Candia, Bertin, Islas, Ángel A., Sánchez-Solano, Alfredo, Millan-Perez Peña, Lourdes, Mancilla-Simbro, Claudia, Salinas-Stefanon, Eduardo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402383/
https://www.ncbi.nlm.nih.gov/pubmed/25904995
http://dx.doi.org/10.1016/j.csbj.2015.03.005

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