The structure of human SFPQ reveals a coiled-coil mediated polymer essential for functional aggregation in gene regulation

SFPQ, (a.k.a. PSF), is a human tumor suppressor protein that regulates many important functions in the cell nucleus including coordination of long non-coding RNA molecules into nuclear bodies. Here we describe the first crystal structures of Splicing Factor Proline and Glutamine Rich (SFPQ), reveali...

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Detalles Bibliográficos
Autores principales: Lee, Mihwa, Sadowska, Agata, Bekere, Indra, Ho, Diwei, Gully, Benjamin S., Lu, Yanling, Iyer, K. Swaminathan, Trewhella, Jill, Fox, Archa H., Bond, Charles S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402515/
https://www.ncbi.nlm.nih.gov/pubmed/25765647
http://dx.doi.org/10.1093/nar/gkv156

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