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H3K9 methyltransferase G9a negatively regulates UHRF1 transcription during leukemia cell differentiation

Histone H3K9 methyltransferase (HMTase) G9a-mediated transcriptional repression is a major epigenetic silencing mechanism. UHRF1 (ubiquitin-like with PHD and ring finger domains 1) binds to hemimethylated DNA and plays an essential role in the maintenance of DNA methylation. Here, we provide evidenc...

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Detalles Bibliográficos
Autores principales:	Kim, Kee-Beom, Son, Hye-Ju, Choi, Sulji, Hahm, Ja Young, Jung, Hyeonsoo, Baek, Hee Jo, Kook, Hoon, Hahn, Yoonsoo, Kook, Hyun, Seo, Sang-Beom
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402520/ https://www.ncbi.nlm.nih.gov/pubmed/25765655 http://dx.doi.org/10.1093/nar/gkv183

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