An Lnc RNA (GAS5)/SnoRNA-derived piRNA induces activation of TRAIL gene by site-specifically recruiting MLL/COMPASS-like complexes

PIWI-interacting RNA (piRNA) silences the transposons in germlines or induces epigenetic modifications in the invertebrates. However, its function in the mammalian somatic cells remains unknown. Here we demonstrate that a piRNA derived from Growth Arrest Specific 5, a tumor-suppressive long non-codi...

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Detalles Bibliográficos
Autores principales: He, Xin, Chen, Xinxin, Zhang, Xue, Duan, Xiaobing, Pan, Ting, Hu, Qifei, Zhang, Yijun, Zhong, Fudi, Liu, Jun, Zhang, Hong, Luo, Juan, Wu, Kang, Peng, Gao, Luo, Haihua, Zhang, Lehong, Li, Xiaoxi, Zhang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402533/
https://www.ncbi.nlm.nih.gov/pubmed/25779046
http://dx.doi.org/10.1093/nar/gkv214

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