Cycloartane Glycosides from the Roots of Cimicifuga foetida with Wnt Signaling Pathway Inhibitory Activity

Four new 9,19-cycloartane triterpenoids, cimilactone E (1), cimilactone F (2), 2′-O-(E)-butenoyl-23-epi-26-deoxyactein (3), and 2′,12β-O-diacetylcimiracemonol-3-O-β-d-xylopyranoside (4), together with four known constituents (5–8) were isolated from the roots of Cimicifuga foetida. The new structure...

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Detalles Bibliográficos
Autores principales: Zhu, Di-Fan, Zhu, Guo-Lei, Kong, Ling-Mei, Bao, Ni-Man, Zhou, Lin, Nian, Yin, Qiu, Ming-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402585/
https://www.ncbi.nlm.nih.gov/pubmed/25693500
http://dx.doi.org/10.1007/s13659-015-0053-7
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author Zhu, Di-Fan
Zhu, Guo-Lei
Kong, Ling-Mei
Bao, Ni-Man
Zhou, Lin
Nian, Yin
Qiu, Ming-Hua
author_facet Zhu, Di-Fan
Zhu, Guo-Lei
Kong, Ling-Mei
Bao, Ni-Man
Zhou, Lin
Nian, Yin
Qiu, Ming-Hua
author_sort Zhu, Di-Fan
collection PubMed
description Four new 9,19-cycloartane triterpenoids, cimilactone E (1), cimilactone F (2), 2′-O-(E)-butenoyl-23-epi-26-deoxyactein (3), and 2′,12β-O-diacetylcimiracemonol-3-O-β-d-xylopyranoside (4), together with four known constituents (5–8) were isolated from the roots of Cimicifuga foetida. The new structures were elucidated by extensive spectroscopic analysis. In addition, compounds 7 and 8 showed significant Wnt signaling pathway inhibitory activity, with IC(50) values of 3.33 and 13.34 μM, respectively, using the luciferase reporter gene assay.
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spelling pubmed-44025852015-04-23 Cycloartane Glycosides from the Roots of Cimicifuga foetida with Wnt Signaling Pathway Inhibitory Activity Zhu, Di-Fan Zhu, Guo-Lei Kong, Ling-Mei Bao, Ni-Man Zhou, Lin Nian, Yin Qiu, Ming-Hua Nat Prod Bioprospect Original Article Four new 9,19-cycloartane triterpenoids, cimilactone E (1), cimilactone F (2), 2′-O-(E)-butenoyl-23-epi-26-deoxyactein (3), and 2′,12β-O-diacetylcimiracemonol-3-O-β-d-xylopyranoside (4), together with four known constituents (5–8) were isolated from the roots of Cimicifuga foetida. The new structures were elucidated by extensive spectroscopic analysis. In addition, compounds 7 and 8 showed significant Wnt signaling pathway inhibitory activity, with IC(50) values of 3.33 and 13.34 μM, respectively, using the luciferase reporter gene assay. Springer Berlin Heidelberg 2015-02-19 /pmc/articles/PMC4402585/ /pubmed/25693500 http://dx.doi.org/10.1007/s13659-015-0053-7 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
Zhu, Di-Fan
Zhu, Guo-Lei
Kong, Ling-Mei
Bao, Ni-Man
Zhou, Lin
Nian, Yin
Qiu, Ming-Hua
Cycloartane Glycosides from the Roots of Cimicifuga foetida with Wnt Signaling Pathway Inhibitory Activity
title Cycloartane Glycosides from the Roots of Cimicifuga foetida with Wnt Signaling Pathway Inhibitory Activity
title_full Cycloartane Glycosides from the Roots of Cimicifuga foetida with Wnt Signaling Pathway Inhibitory Activity
title_fullStr Cycloartane Glycosides from the Roots of Cimicifuga foetida with Wnt Signaling Pathway Inhibitory Activity
title_full_unstemmed Cycloartane Glycosides from the Roots of Cimicifuga foetida with Wnt Signaling Pathway Inhibitory Activity
title_short Cycloartane Glycosides from the Roots of Cimicifuga foetida with Wnt Signaling Pathway Inhibitory Activity
title_sort cycloartane glycosides from the roots of cimicifuga foetida with wnt signaling pathway inhibitory activity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402585/
https://www.ncbi.nlm.nih.gov/pubmed/25693500
http://dx.doi.org/10.1007/s13659-015-0053-7
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