How does the Merkel polyomavirus lead to a lethal cancer? Many answers, many questions, and a new mouse model

The Merkel cell polyomavirus (MCPyV), discovered in 2008, drives development of most Merkel cell carcinomas (MCCs) through several canonical mechanisms. A glaring gap in our knowledge remains the basis by which MCPyV, among all 12 human polyomaviruses, is the only one that causes cancer in humans. M...

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Detalles Bibliográficos
Autores principales: Church, Candice, Nghiem, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402710/
https://www.ncbi.nlm.nih.gov/pubmed/25882464
http://dx.doi.org/10.1038/jid.2015.4
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author Church, Candice
Nghiem, Paul
author_facet Church, Candice
Nghiem, Paul
author_sort Church, Candice
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description The Merkel cell polyomavirus (MCPyV), discovered in 2008, drives development of most Merkel cell carcinomas (MCCs) through several canonical mechanisms. A glaring gap in our knowledge remains the basis by which MCPyV, among all 12 human polyomaviruses, is the only one that causes cancer in humans. Moreover, initial attempts by numerous groups have failed to reproduce MCC in mice using oncoproteins from this polyomavirus. Verhaegen at al. report MCPyV small T antigen-expressing transgenic mice that now provide insight into in vivo transformation mechanisms.
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spelling pubmed-44027102015-11-01 How does the Merkel polyomavirus lead to a lethal cancer? Many answers, many questions, and a new mouse model Church, Candice Nghiem, Paul J Invest Dermatol Article The Merkel cell polyomavirus (MCPyV), discovered in 2008, drives development of most Merkel cell carcinomas (MCCs) through several canonical mechanisms. A glaring gap in our knowledge remains the basis by which MCPyV, among all 12 human polyomaviruses, is the only one that causes cancer in humans. Moreover, initial attempts by numerous groups have failed to reproduce MCC in mice using oncoproteins from this polyomavirus. Verhaegen at al. report MCPyV small T antigen-expressing transgenic mice that now provide insight into in vivo transformation mechanisms. 2015-05 /pmc/articles/PMC4402710/ /pubmed/25882464 http://dx.doi.org/10.1038/jid.2015.4 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Church, Candice
Nghiem, Paul
How does the Merkel polyomavirus lead to a lethal cancer? Many answers, many questions, and a new mouse model
title How does the Merkel polyomavirus lead to a lethal cancer? Many answers, many questions, and a new mouse model
title_full How does the Merkel polyomavirus lead to a lethal cancer? Many answers, many questions, and a new mouse model
title_fullStr How does the Merkel polyomavirus lead to a lethal cancer? Many answers, many questions, and a new mouse model
title_full_unstemmed How does the Merkel polyomavirus lead to a lethal cancer? Many answers, many questions, and a new mouse model
title_short How does the Merkel polyomavirus lead to a lethal cancer? Many answers, many questions, and a new mouse model
title_sort how does the merkel polyomavirus lead to a lethal cancer? many answers, many questions, and a new mouse model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402710/
https://www.ncbi.nlm.nih.gov/pubmed/25882464
http://dx.doi.org/10.1038/jid.2015.4
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