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Clinical and immunological relevance of anti-neuronal antibodies in celiac disease with neurological manifestations

AIM: To assess anti-neuronal antibodies (NA) prevalence and their correlation with neurological disorders and bowel habits in celiac disease (CD) patients. BACKGROUND: Neurological manifestations are estimated to occur in about 10% of celiac disease patients and NA to central nervous system (CNS) an...

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Autores principales: Caio, Giacomo, Giorgio, Roberto De, Venturi, Alessandro, Giancola, Fiorella, Latorre, Rocco, Boschetti, Elisa, Serra, Mauro, Ruggeri, Eugenio, Volta, Umberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403027/
https://www.ncbi.nlm.nih.gov/pubmed/25926940
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author Caio, Giacomo
Giorgio, Roberto De
Venturi, Alessandro
Giancola, Fiorella
Latorre, Rocco
Boschetti, Elisa
Serra, Mauro
Ruggeri, Eugenio
Volta, Umberto
author_facet Caio, Giacomo
Giorgio, Roberto De
Venturi, Alessandro
Giancola, Fiorella
Latorre, Rocco
Boschetti, Elisa
Serra, Mauro
Ruggeri, Eugenio
Volta, Umberto
author_sort Caio, Giacomo
collection PubMed
description AIM: To assess anti-neuronal antibodies (NA) prevalence and their correlation with neurological disorders and bowel habits in celiac disease (CD) patients. BACKGROUND: Neurological manifestations are estimated to occur in about 10% of celiac disease patients and NA to central nervous system (CNS) and enteric nervous system (ENS) are found in a significant proportion of them. Little is known about the clinical and immunological features in CD patients with neurological manifestations. PATIENTS AND METHODS: NA to CNS and ENS were investigated in 106 CD patients and in 60 controls with autoimmune disorders by indirect immunofluorescence on rat / primate cerebellar cortex and intestinal (small and large bowel) sections. RESULTS: IgG NA to CNS (titer 1:50 - 1:400) were positive in 23 celiacs (21%), being more frequently detected in those with neurological disorders that in those without neurological dysfunction (49% vs. 8%, P< 0.0001). Of the 26 celiacs (24%) with IgG NA to ENS, 11 out of 12 with an antibody titer > 1:200 had severe constipation. Only one patient with cerebellar ataxia and intestinal sub-occlusion was positive for NA to CNS and ENS. NA to CNS and ENS were found in 7% and 5% of controls, respectively. CONCLUSION: In CD the positivity of NA to CNS can be regarded as a marker of neurological manifestations. High titer NA to ENS are associated with severe constipation. The demonstration of NA to CNS and ENS suggests an immune-mediated pathogenesis leading to central neural impairment as well as gut dysfunction (hence constipation), respectively.
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spelling pubmed-44030272015-04-29 Clinical and immunological relevance of anti-neuronal antibodies in celiac disease with neurological manifestations Caio, Giacomo Giorgio, Roberto De Venturi, Alessandro Giancola, Fiorella Latorre, Rocco Boschetti, Elisa Serra, Mauro Ruggeri, Eugenio Volta, Umberto Gastroenterol Hepatol Bed Bench Original Article AIM: To assess anti-neuronal antibodies (NA) prevalence and their correlation with neurological disorders and bowel habits in celiac disease (CD) patients. BACKGROUND: Neurological manifestations are estimated to occur in about 10% of celiac disease patients and NA to central nervous system (CNS) and enteric nervous system (ENS) are found in a significant proportion of them. Little is known about the clinical and immunological features in CD patients with neurological manifestations. PATIENTS AND METHODS: NA to CNS and ENS were investigated in 106 CD patients and in 60 controls with autoimmune disorders by indirect immunofluorescence on rat / primate cerebellar cortex and intestinal (small and large bowel) sections. RESULTS: IgG NA to CNS (titer 1:50 - 1:400) were positive in 23 celiacs (21%), being more frequently detected in those with neurological disorders that in those without neurological dysfunction (49% vs. 8%, P< 0.0001). Of the 26 celiacs (24%) with IgG NA to ENS, 11 out of 12 with an antibody titer > 1:200 had severe constipation. Only one patient with cerebellar ataxia and intestinal sub-occlusion was positive for NA to CNS and ENS. NA to CNS and ENS were found in 7% and 5% of controls, respectively. CONCLUSION: In CD the positivity of NA to CNS can be regarded as a marker of neurological manifestations. High titer NA to ENS are associated with severe constipation. The demonstration of NA to CNS and ENS suggests an immune-mediated pathogenesis leading to central neural impairment as well as gut dysfunction (hence constipation), respectively. Shaheed Beheshti University of Medical Sciences 2015 /pmc/articles/PMC4403027/ /pubmed/25926940 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Caio, Giacomo
Giorgio, Roberto De
Venturi, Alessandro
Giancola, Fiorella
Latorre, Rocco
Boschetti, Elisa
Serra, Mauro
Ruggeri, Eugenio
Volta, Umberto
Clinical and immunological relevance of anti-neuronal antibodies in celiac disease with neurological manifestations
title Clinical and immunological relevance of anti-neuronal antibodies in celiac disease with neurological manifestations
title_full Clinical and immunological relevance of anti-neuronal antibodies in celiac disease with neurological manifestations
title_fullStr Clinical and immunological relevance of anti-neuronal antibodies in celiac disease with neurological manifestations
title_full_unstemmed Clinical and immunological relevance of anti-neuronal antibodies in celiac disease with neurological manifestations
title_short Clinical and immunological relevance of anti-neuronal antibodies in celiac disease with neurological manifestations
title_sort clinical and immunological relevance of anti-neuronal antibodies in celiac disease with neurological manifestations
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403027/
https://www.ncbi.nlm.nih.gov/pubmed/25926940
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