Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology

Drugs targeting atrial-specific ion channels, K(v)1.5 or K(ir)3.1/3.4, are being developed as new therapeutic strategies for atrial fibrillation. However, current preclinical studies carried out in non-cardiac cell lines or animal models may not accurately represent the physiology of a human cardiom...

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Detalles Bibliográficos
Autores principales: Devalla, Harsha D, Schwach, Verena, Ford, John W, Milnes, James T, El-Haou, Said, Jackson, Claire, Gkatzis, Konstantinos, Elliott, David A, Chuva de Sousa Lopes, Susana M, Mummery, Christine L, Verkerk, Arie O, Passier, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403042/
https://www.ncbi.nlm.nih.gov/pubmed/25700171
http://dx.doi.org/10.15252/emmm.201404757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403042/
https://www.ncbi.nlm.nih.gov/pubmed/25700171
http://dx.doi.org/10.15252/emmm.201404757

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