Cargando…

Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology

Drugs targeting atrial-specific ion channels, K(v)1.5 or K(ir)3.1/3.4, are being developed as new therapeutic strategies for atrial fibrillation. However, current preclinical studies carried out in non-cardiac cell lines or animal models may not accurately represent the physiology of a human cardiom...

Descripción completa

Detalles Bibliográficos
Autores principales:	Devalla, Harsha D, Schwach, Verena, Ford, John W, Milnes, James T, El-Haou, Said, Jackson, Claire, Gkatzis, Konstantinos, Elliott, David A, Chuva de Sousa Lopes, Susana M, Mummery, Christine L, Verkerk, Arie O, Passier, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403042/ https://www.ncbi.nlm.nih.gov/pubmed/25700171 http://dx.doi.org/10.15252/emmm.201404757

Ejemplares similares

A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes
por: Schwach, Verena, et al.
Publicado: (2017)

Ultrarapid Delayed Rectifier K(+) Channelopathies in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
por: Hilderink, Sarah, et al.
Publicado: (2020)

Human Pluripotent Stem Cell-Derived Cardiomyocytes for Assessment of Anticancer Drug-Induced Cardiotoxicity
por: Schwach, Verena, et al.
Publicado: (2020)

Improved Atrial Differentiation of Human Pluripotent Stem Cells by Activation of Retinoic Acid Receptor Alpha (RARα)
por: Schwach, Verena, et al.
Publicado: (2022)

Towards Improved Human In Vitro Models for Cardiac Arrhythmia: Disease Mechanisms, Treatment, and Models of Atrial Fibrillation
por: Cofiño-Fabres, Carla, et al.
Publicado: (2023)

Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmias
por: Hoekstra, Maaike, et al.
Publicado: (2012)

Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia
por: Thorpe, Jordan, et al.
Publicado: (2023)

The positive frequency-dependent electrophysiological effects of the I(Kur) inhibitor XEN-D0103 are desirable for the treatment of atrial fibrillation
por: Ford, John, et al.
Publicado: (2016)

Human-induced pluripotent stem cell-atrial-specific cardiomyocytes and atrial fibrillation
por: Leowattana, Wattana, et al.
Publicado: (2022)

Cryopreservation of human pluripotent stem cell-derived cardiomyocytes is not detrimental to their molecular and functional properties
por: van den Brink, Lettine, et al.
Publicado: (2020)

Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models
por: Li, Jiuru, et al.
Publicado: (2022)

Are atrial human pluripotent stem cell-derived cardiomyocytes ready to identify drugs that beat atrial fibrillation?
por: Christ, Torsten, et al.
Publicado: (2021)

Reply to ‘Are atrial human pluripotent stem cell-derived cardiomyocytes ready to identify drugs that beat atrial fibrillation?’
por: Shiti, Assad, et al.
Publicado: (2021)

Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes
por: Tertoolen, L.G.J., et al.
Publicado: (2018)

Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function
por: Birket, Matthew J., et al.
Publicado: (2015)

Electrophysiologic Characterization of Calcium Handling in Human Induced Pluripotent Stem Cell-Derived Atrial Cardiomyocytes
por: Argenziano, Mariana, et al.
Publicado: (2018)

Perspectives on the Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Biomedical Research
por: Mummery, Christine L.
Publicado: (2018)

Cardiovascular development: towards biomedical applicability: Regulation of cardiomyocyte differentiation of embryonic stem cells by extracellular signalling
por: Filipczyk, A. A., et al.
Publicado: (2007)

Absence of Functional Na(v)1.8 Channels in Non-diseased Atrial and Ventricular Cardiomyocytes
por: Casini, Simona, et al.
Publicado: (2020)

Automated image analysis system for studying cardiotoxicity in human pluripotent stem cell-Derived cardiomyocytes
por: Cao, Lu, et al.
Publicado: (2020)

Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes
por: Giacomelli, E., et al.
Publicado: (2017)

Effects of I(Kur) blocker MK-0448 on human right atrial action potentials from patients in sinus rhythm and in permanent atrial fibrillation
por: Loose, Simone, et al.
Publicado: (2014)

Memantine targets glutamate receptors in atrial cardiomyocytes to prevent and treat atrial fibrillation
por: Xie, Duanyang, et al.
Publicado: (2022)

Identification and Purification of Human Induced Pluripotent Stem Cell-Derived Atrial-Like Cardiomyocytes Based on Sarcolipin Expression
por: Josowitz, Rebecca, et al.
Publicado: (2014)

Long Non-Coding RNAs in Atrial Fibrillation: Pluripotent Stem Cell-Derived Cardiomyocytes as a Model System
por: Bektik, Emre, et al.
Publicado: (2020)

Drug screening platform using human induced pluripotent stem cell‐derived atrial cardiomyocytes and optical mapping
por: Gunawan, Marvin G., et al.
Publicado: (2020)

Acetylcholine Delays Atrial Activation to Facilitate Atrial Fibrillation
por: Bayer, Jason D., et al.
Publicado: (2019)

Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come?
por: Sala, Luca, et al.
Publicado: (2016)

Effects of Acetylcholine and Noradrenalin on Action Potentials of Isolated Rabbit Sinoatrial and Atrial Myocytes
por: Verkerk, Arie O., et al.
Publicado: (2012)

KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas
por: Roost, Matthias S., et al.
Publicado: (2015)

Human induced pluripotent stem cell-derived atrial cardiomyocytes carrying an SCN5A mutation identify nitric oxide signaling as a mediator of atrial fibrillation
por: Hong, Liang, et al.
Publicado: (2021)

Identification of atrial-enriched lncRNA Walras linked to cardiomyocyte cytoarchitecture and atrial fibrillation
por: García-Padilla, Carlos, et al.
Publicado: (2022)

Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology
por: Dobrev, Dobromir, et al.
Publicado: (2022)

Effects of hydroxychloroquine on atrial electrophysiology in in silico wild-type and PITX2(+/-) atrial cardiomyocytes
por: Song, Euijun
Publicado: (2023)

Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes
por: Goldfracht, Idit, et al.
Publicado: (2020)

Comparative analysis of the cardiomyocyte differentiation potential of induced pluripotent stem cells reprogrammed from human atrial or ventricular fibroblasts
por: Wang, Lu, et al.
Publicado: (2023)

Generation of cardiomyocytes from human-induced pluripotent stem cells resembling atrial cells with ability to respond to adrenoceptor agonists
por: Ahmad, Faizzan S., et al.
Publicado: (2023)

Patch-Clamp Recording from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Improving Action Potential Characteristics through Dynamic Clamp
por: Verkerk, Arie O., et al.
Publicado: (2017)

A single cell transcriptional roadmap of human pacemaker cell differentiation
por: Wiesinger, Alexandra, et al.
Publicado: (2022)

Late Sodium Current in Human Atrial Cardiomyocytes from Patients in Sinus Rhythm and Atrial Fibrillation
por: Poulet, Claire, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_f8ppogotmmkfjeserum8suokh1