Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives

A series of novel 2-aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine derivatives have been synthesized and their antiplatelet aggregation activities were assessed against ADP and arachidonic acid-induced platelet aggregation in human plasma using light transmission aggregometry. Among the tes...

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Autores principales: Esfahanizadeh, Marjan, Mohebbi, Shohreh, Dasht Bozorg, Behnam, Amidi, Salimeh, Gudarzi, Ali, Ayatollahi, Seyed Abdolmajid, Kobarfard, Farzad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403057/
https://www.ncbi.nlm.nih.gov/pubmed/25901148
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author Esfahanizadeh, Marjan
Mohebbi, Shohreh
Dasht Bozorg, Behnam
Amidi, Salimeh
Gudarzi, Ali
Ayatollahi, Seyed Abdolmajid
Kobarfard, Farzad
author_facet Esfahanizadeh, Marjan
Mohebbi, Shohreh
Dasht Bozorg, Behnam
Amidi, Salimeh
Gudarzi, Ali
Ayatollahi, Seyed Abdolmajid
Kobarfard, Farzad
author_sort Esfahanizadeh, Marjan
collection PubMed
description A series of novel 2-aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine derivatives have been synthesized and their antiplatelet aggregation activities were assessed against ADP and arachidonic acid-induced platelet aggregation in human plasma using light transmission aggregometry. Among the tested derivatives, compounds Ia, I(b), I(B) and II(16) exhibited the highest antiplatelet aggregation activity (36.75, 72.4, 62.5 and 80 µM). None of the compounds showed satisfactory activity against the aggregation induced by ADP but acceptable activities were observed against the aggregation induced by arachidonic acid. 2- aminopyrimidines were more active than 4,6- diaminopyrimidines in this respect.
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spelling pubmed-44030572015-04-21 Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives Esfahanizadeh, Marjan Mohebbi, Shohreh Dasht Bozorg, Behnam Amidi, Salimeh Gudarzi, Ali Ayatollahi, Seyed Abdolmajid Kobarfard, Farzad Iran J Pharm Res Original Article A series of novel 2-aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine derivatives have been synthesized and their antiplatelet aggregation activities were assessed against ADP and arachidonic acid-induced platelet aggregation in human plasma using light transmission aggregometry. Among the tested derivatives, compounds Ia, I(b), I(B) and II(16) exhibited the highest antiplatelet aggregation activity (36.75, 72.4, 62.5 and 80 µM). None of the compounds showed satisfactory activity against the aggregation induced by ADP but acceptable activities were observed against the aggregation induced by arachidonic acid. 2- aminopyrimidines were more active than 4,6- diaminopyrimidines in this respect. Shaheed Beheshti University of Medical Sciences 2015 /pmc/articles/PMC4403057/ /pubmed/25901148 Text en © 2015 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Esfahanizadeh, Marjan
Mohebbi, Shohreh
Dasht Bozorg, Behnam
Amidi, Salimeh
Gudarzi, Ali
Ayatollahi, Seyed Abdolmajid
Kobarfard, Farzad
Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives
title Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives
title_full Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives
title_fullStr Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives
title_full_unstemmed Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives
title_short Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives
title_sort synthesis and antiplatelet aggregation activity evaluation of some 2-aminopyrimidine and 2-substituted-4,6-diaminopyrimidine derivatives
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403057/
https://www.ncbi.nlm.nih.gov/pubmed/25901148
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