Voltammetric Behavior and Determination of Trace Amounts of Omeprazole Using an Edge-plane Pyrolytic Graphite Electrode

The voltammetric performance of edge-plane pyrolytic graphite (EPG) electrode via adsorptive stripping voltammetry was investigated for study of the electrochemical behavior of omeprazole (OMZ) in aqueous solution. The results revealed that the oxidation of OMZ is an irreversible pH-dependent proces...

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Autores principales: Shahrokhian, Saeed, Ghalkhani, Masoumeh, Bayat, Maryam, Ghorbani-Bidkorbeh, Fatemeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403062/
https://www.ncbi.nlm.nih.gov/pubmed/25901153
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author Shahrokhian, Saeed
Ghalkhani, Masoumeh
Bayat, Maryam
Ghorbani-Bidkorbeh, Fatemeh
author_facet Shahrokhian, Saeed
Ghalkhani, Masoumeh
Bayat, Maryam
Ghorbani-Bidkorbeh, Fatemeh
author_sort Shahrokhian, Saeed
collection PubMed
description The voltammetric performance of edge-plane pyrolytic graphite (EPG) electrode via adsorptive stripping voltammetry was investigated for study of the electrochemical behavior of omeprazole (OMZ) in aqueous solution. The results revealed that the oxidation of OMZ is an irreversible pH-dependent process that proceeds with the transfer of one electron and one proton in an adsorption-controlled mechanism. The determination conditions, such as the pH values of the supporting electrolyte, accumulation time and scan rate were optimized. Simplicity, high reproducibility and low detection limit (3 nM) of the electrode response as well as wide linear range (0.01 to 4.0 µM) can be stated as significant features of this electrode. The EPG electrode was successfully applied for the determination of OMZ in pharmaceutical formulations and satisfactory results were obtained.
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spelling pubmed-44030622015-04-21 Voltammetric Behavior and Determination of Trace Amounts of Omeprazole Using an Edge-plane Pyrolytic Graphite Electrode Shahrokhian, Saeed Ghalkhani, Masoumeh Bayat, Maryam Ghorbani-Bidkorbeh, Fatemeh Iran J Pharm Res Original Article The voltammetric performance of edge-plane pyrolytic graphite (EPG) electrode via adsorptive stripping voltammetry was investigated for study of the electrochemical behavior of omeprazole (OMZ) in aqueous solution. The results revealed that the oxidation of OMZ is an irreversible pH-dependent process that proceeds with the transfer of one electron and one proton in an adsorption-controlled mechanism. The determination conditions, such as the pH values of the supporting electrolyte, accumulation time and scan rate were optimized. Simplicity, high reproducibility and low detection limit (3 nM) of the electrode response as well as wide linear range (0.01 to 4.0 µM) can be stated as significant features of this electrode. The EPG electrode was successfully applied for the determination of OMZ in pharmaceutical formulations and satisfactory results were obtained. Shaheed Beheshti University of Medical Sciences 2015 /pmc/articles/PMC4403062/ /pubmed/25901153 Text en © 2015 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Shahrokhian, Saeed
Ghalkhani, Masoumeh
Bayat, Maryam
Ghorbani-Bidkorbeh, Fatemeh
Voltammetric Behavior and Determination of Trace Amounts of Omeprazole Using an Edge-plane Pyrolytic Graphite Electrode
title Voltammetric Behavior and Determination of Trace Amounts of Omeprazole Using an Edge-plane Pyrolytic Graphite Electrode
title_full Voltammetric Behavior and Determination of Trace Amounts of Omeprazole Using an Edge-plane Pyrolytic Graphite Electrode
title_fullStr Voltammetric Behavior and Determination of Trace Amounts of Omeprazole Using an Edge-plane Pyrolytic Graphite Electrode
title_full_unstemmed Voltammetric Behavior and Determination of Trace Amounts of Omeprazole Using an Edge-plane Pyrolytic Graphite Electrode
title_short Voltammetric Behavior and Determination of Trace Amounts of Omeprazole Using an Edge-plane Pyrolytic Graphite Electrode
title_sort voltammetric behavior and determination of trace amounts of omeprazole using an edge-plane pyrolytic graphite electrode
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403062/
https://www.ncbi.nlm.nih.gov/pubmed/25901153
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