Sex-Dependent Vulnerability to Cannabis Abuse in Adolescence

The goal of this review is to summarize current evidence for sex differences in the response to cannabinoid compounds, focusing mainly on a specific age of exposure, i.e., adolescence. Preclinical as well as clinical studies are examined. Among the different possible underlying mechanisms, the consi...

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Detalles Bibliográficos
Autores principales: Rubino, Tiziana, Parolaro, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403248/
https://www.ncbi.nlm.nih.gov/pubmed/25941498
http://dx.doi.org/10.3389/fpsyt.2015.00056
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author Rubino, Tiziana
Parolaro, Daniela
author_facet Rubino, Tiziana
Parolaro, Daniela
author_sort Rubino, Tiziana
collection PubMed
description The goal of this review is to summarize current evidence for sex differences in the response to cannabinoid compounds, focusing mainly on a specific age of exposure, i.e., adolescence. Preclinical as well as clinical studies are examined. Among the different possible underlying mechanisms, the consistent dimorphism in the endocannabinoid system and delta9-tetrahydrocannabinol metabolism may play a part. All the collected data point to the need of including females in basic research as well as of analyzing results for sex differences in epidemiological studies.
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spelling pubmed-44032482015-05-04 Sex-Dependent Vulnerability to Cannabis Abuse in Adolescence Rubino, Tiziana Parolaro, Daniela Front Psychiatry Psychiatry The goal of this review is to summarize current evidence for sex differences in the response to cannabinoid compounds, focusing mainly on a specific age of exposure, i.e., adolescence. Preclinical as well as clinical studies are examined. Among the different possible underlying mechanisms, the consistent dimorphism in the endocannabinoid system and delta9-tetrahydrocannabinol metabolism may play a part. All the collected data point to the need of including females in basic research as well as of analyzing results for sex differences in epidemiological studies. Frontiers Media S.A. 2015-04-20 /pmc/articles/PMC4403248/ /pubmed/25941498 http://dx.doi.org/10.3389/fpsyt.2015.00056 Text en Copyright © 2015 Rubino and Parolaro. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Rubino, Tiziana
Parolaro, Daniela
Sex-Dependent Vulnerability to Cannabis Abuse in Adolescence
title Sex-Dependent Vulnerability to Cannabis Abuse in Adolescence
title_full Sex-Dependent Vulnerability to Cannabis Abuse in Adolescence
title_fullStr Sex-Dependent Vulnerability to Cannabis Abuse in Adolescence
title_full_unstemmed Sex-Dependent Vulnerability to Cannabis Abuse in Adolescence
title_short Sex-Dependent Vulnerability to Cannabis Abuse in Adolescence
title_sort sex-dependent vulnerability to cannabis abuse in adolescence
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403248/
https://www.ncbi.nlm.nih.gov/pubmed/25941498
http://dx.doi.org/10.3389/fpsyt.2015.00056
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AT parolarodaniela sexdependentvulnerabilitytocannabisabuseinadolescence

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