Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin

The bone microenvironment is composed of niches that house cells across variable oxygen tensions. However, the contribution of oxygen gradients in regulating bone and blood homeostasis remains unknown. Here, we generated mice with either single or combined genetic inactivation of the critical oxygen...

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Detalles Bibliográficos
Autores principales: Wu, Colleen, Rankin, Erinn B., Castellini, Laura, Fernandez-Alcudia, Javier, LaGory, Edward L., Andersen, Rebecca, Rhodes, Steven D., Wilson, Tremika L.S., Mohammad, Khalid S., Castillo, Alesha B., Guise, Theresa A., Schipani, Ernestina, Giaccia, Amato J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403258/
https://www.ncbi.nlm.nih.gov/pubmed/25846796
http://dx.doi.org/10.1101/gad.255000.114

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