Synonymous modification results in high-fidelity gene expression of repetitive protein and nucleotide sequences

Repetitive nucleotide or amino acid sequences are often engineered into probes and biosensors to achieve functional readouts and robust signal amplification. However, these repeated sequences are notoriously prone to aberrant deletion and degradation, impacting the ability to correctly detect and in...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Bin, Miskolci, Veronika, Sato, Hanae, Tutucci, Evelina, Kenworthy, Charles A., Donnelly, Sara K., Yoon, Young J., Cox, Dianne, Singer, Robert H., Hodgson, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Resource/Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403262/
https://www.ncbi.nlm.nih.gov/pubmed/25877922
http://dx.doi.org/10.1101/gad.259358.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403262/
https://www.ncbi.nlm.nih.gov/pubmed/25877922
http://dx.doi.org/10.1101/gad.259358.115

Ejemplares similares